The posterior parahippocampal gyrus is preferentially affected in age-related memory decline

S. Burgmans, M.P.J. van Boxtel, K.E.M. Berg, E.H.B.M. Gronenschild, H.I.L. Jacobs, J. Jolles, H.B.M. Uylings

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

Atrophy in the medial temporal lobe is generally considered to be highly associated with age-related memory decline. Volume loss in the hippocampus and entorhinal cortex has extensively been investigated, but the posterior parts of the parahippocampal gyrus have received little attention. The present MRI study investigated whether volume differences in medial temporal lobe areas are differentially related to age-related memory decline. Thirty-nine subjects from a longitudinal study on cognitive aging (the Maastricht Aging Study) have been examined: 20 participants (mean age=67 years, range 52-80) with memory decline over a period of 12 years were matched to 19 participants without memory decline. Manual tracing was performed on 3T MR images to measure the volumes of the anterior, middle and posterior parts of the hippocampus and parahippocampal gyrus. A robust group difference and a significant association with memory decline were observed only in the posterior part of the parahippocampal gyrus. Our results may suggest that the posterior parahippocampal gyrus plays a key role in age-related memory decline.
Original languageEnglish
Pages (from-to)1572-1578
Number of pages7
JournalNeurobiology of Aging
Volume32
Issue number9
DOIs
Publication statusPublished - Sep 2011

Keywords

  • MTL
  • Hippocampus
  • Aging
  • Gray matter atrophy
  • Volumetry
  • MRI
  • Human
  • MEDIAL TEMPORAL-LOBE
  • ALZHEIMERS-DISEASE
  • ENTORHINAL CORTEX
  • CORTICAL AFFERENTS
  • MONKEY
  • ORGANIZATION
  • PERFORMANCE
  • VOLUME
  • POPULATION
  • DEMENTIA

Cite this

Burgmans, S. ; van Boxtel, M.P.J. ; Berg, K.E.M. ; Gronenschild, E.H.B.M. ; Jacobs, H.I.L. ; Jolles, J. ; Uylings, H.B.M. / The posterior parahippocampal gyrus is preferentially affected in age-related memory decline. In: Neurobiology of Aging. 2011 ; Vol. 32, No. 9. pp. 1572-1578.
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abstract = "Atrophy in the medial temporal lobe is generally considered to be highly associated with age-related memory decline. Volume loss in the hippocampus and entorhinal cortex has extensively been investigated, but the posterior parts of the parahippocampal gyrus have received little attention. The present MRI study investigated whether volume differences in medial temporal lobe areas are differentially related to age-related memory decline. Thirty-nine subjects from a longitudinal study on cognitive aging (the Maastricht Aging Study) have been examined: 20 participants (mean age=67 years, range 52-80) with memory decline over a period of 12 years were matched to 19 participants without memory decline. Manual tracing was performed on 3T MR images to measure the volumes of the anterior, middle and posterior parts of the hippocampus and parahippocampal gyrus. A robust group difference and a significant association with memory decline were observed only in the posterior part of the parahippocampal gyrus. Our results may suggest that the posterior parahippocampal gyrus plays a key role in age-related memory decline.",
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The posterior parahippocampal gyrus is preferentially affected in age-related memory decline. / Burgmans, S.; van Boxtel, M.P.J.; Berg, K.E.M.; Gronenschild, E.H.B.M.; Jacobs, H.I.L.; Jolles, J.; Uylings, H.B.M.

In: Neurobiology of Aging, Vol. 32, No. 9, 09.2011, p. 1572-1578.

Research output: Contribution to journalArticleAcademicpeer-review

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AU - Jolles, J.

AU - Uylings, H.B.M.

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AB - Atrophy in the medial temporal lobe is generally considered to be highly associated with age-related memory decline. Volume loss in the hippocampus and entorhinal cortex has extensively been investigated, but the posterior parts of the parahippocampal gyrus have received little attention. The present MRI study investigated whether volume differences in medial temporal lobe areas are differentially related to age-related memory decline. Thirty-nine subjects from a longitudinal study on cognitive aging (the Maastricht Aging Study) have been examined: 20 participants (mean age=67 years, range 52-80) with memory decline over a period of 12 years were matched to 19 participants without memory decline. Manual tracing was performed on 3T MR images to measure the volumes of the anterior, middle and posterior parts of the hippocampus and parahippocampal gyrus. A robust group difference and a significant association with memory decline were observed only in the posterior part of the parahippocampal gyrus. Our results may suggest that the posterior parahippocampal gyrus plays a key role in age-related memory decline.

KW - MTL

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KW - Gray matter atrophy

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KW - ALZHEIMERS-DISEASE

KW - ENTORHINAL CORTEX

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