The multiple sclerosis susceptibility genes TAGAP and IL2RA are regulated by vitamin D in CD4+T cells

T. Berge*, I. S. Leikfoss, I. S. Brorson, S. D. Bos, C. M. Page, M. W. Gustavsen, A. Bjolgerud, T. Holmoy, E. G. Celius, J. Damoiseaux, J. Smolders, H. F. Harbo, A. Spurkland

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Multiple sclerosis (MS) is an inflammatory, demyelinating disorder of the central nervous system that develops in genetically susceptible individuals. The majority of the MS-associated gene variants are located in genetic regions with importance for T-cell differentiation. Vitamin D is a potent immunomodulator, and vitamin D deficiency has been suggested to be associated with increased MS disease susceptibility and activity. In CD4+ T cells, we have analyzed in vitro vitamin D responsiveness of genes that contain an MS-associated single-nucleotide polymorphism (SNP) and with one or more vitamin D response elements in their regulatory regions. We identify IL2RA and TAGAP as novel vitamin D target genes. The vitamin D response is observed in samples from both MS patients and controls, and is not dependent on the genotype of MS-associated SNPs in the respective genes.
Original languageEnglish
Pages (from-to)118-127
JournalGenes and Immunity
Issue number2
Publication statusPublished - Mar 2016

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