The Metabolic Syndrome and Carotid Intima-Media Thickness in Relation to the Parathyroid Hormone to 25-OH-D-3 Ratio in a General Population

Tom Richart; Lutgarde Thijs; Tim Nawrot; Jin Yu; Tatiana Kuznetsova; Elisabeth J. Balkestein; Harry A. Struijker-Boudier; Jan A. Staessen

doi:10.1038/ajh.2010.124

The Metabolic Syndrome and Carotid Intima-Media Thickness in Relation to the Parathyroid Hormone to 25-OH-D-3 Ratio in a General Population

Tom Richart^*, Lutgarde Thijs, Tim Nawrot, Jin Yu, Tatiana Kuznetsova, Elisabeth J. Balkestein, Harry A. Struijker-Boudier, Jan A. Staessen

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

BACKGROUND Parathyroid hormone (PTH) and vitamin D interactively regulate calcium fluxes across membranes, and thereby modulate insulin sensitivity, blood pressure, and arterial calcification. We hypothesized that lower calcium intake as reflected by circulating PTH and 25-OH-D-3 might be associated with the metabolic syndrome (MS) and arterial calcification. METHODS In a random population sample (n = 542; 50.5% women; mean age, 49.8 +/- 13.1 years), we measured MS prevalence (International Diabetes Federation (IDF) and American Heart Association (AHA) criteria), PTH and 25-OH-D-3, serum and 24-h urinary calcium, MS components, carotid intima-media thickness (CIMT), and calcium intake from dairy products. We assessed associations in multivariable-adjusted analyses, using linear and logistic regressions. RESULTS The prevalence of MS was 21.0% (IDF criteria) and 23.6% (AHA criteria). MS prevalence, blood pressure, waist circumference, body mass index, fasting blood glucose, insulin and triglycerides, and CIMT increased (P

Original language	English
Pages (from-to)	102-109
Journal	American Journal of Hypertension
Volume	24
Issue number	1
DOIs	https://doi.org/10.1038/ajh.2010.124
Publication status	Published - Jan 2011

Keywords

25-OH-D-3
blood pressure
calcium
hypertension
insulin resistance
intima-media thickness
metabolic syndrome
PTH
vitamin D

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10.1038/ajh.2010.124

Cite this

@article{cb0455f53ae447d2914f5bd25b948bfd,

title = "The Metabolic Syndrome and Carotid Intima-Media Thickness in Relation to the Parathyroid Hormone to 25-OH-D-3 Ratio in a General Population",

abstract = "BACKGROUND Parathyroid hormone (PTH) and vitamin D interactively regulate calcium fluxes across membranes, and thereby modulate insulin sensitivity, blood pressure, and arterial calcification. We hypothesized that lower calcium intake as reflected by circulating PTH and 25-OH-D-3 might be associated with the metabolic syndrome (MS) and arterial calcification. METHODS In a random population sample (n = 542; 50.5% women; mean age, 49.8 +/- 13.1 years), we measured MS prevalence (International Diabetes Federation (IDF) and American Heart Association (AHA) criteria), PTH and 25-OH-D-3, serum and 24-h urinary calcium, MS components, carotid intima-media thickness (CIMT), and calcium intake from dairy products. We assessed associations in multivariable-adjusted analyses, using linear and logistic regressions. RESULTS The prevalence of MS was 21.0% (IDF criteria) and 23.6% (AHA criteria). MS prevalence, blood pressure, waist circumference, body mass index, fasting blood glucose, insulin and triglycerides, and CIMT increased (P ",

keywords = "25-OH-D-3, blood pressure, calcium, hypertension, insulin resistance, intima-media thickness, metabolic syndrome, PTH, vitamin D",

author = "Tom Richart and Lutgarde Thijs and Tim Nawrot and Jin Yu and Tatiana Kuznetsova and Balkestein, {Elisabeth J.} and Struijker-Boudier, {Harry A.} and Staessen, {Jan A.}",

year = "2011",

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doi = "10.1038/ajh.2010.124",

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AU - Richart, Tom

AU - Thijs, Lutgarde

AU - Nawrot, Tim

AU - Yu, Jin

AU - Kuznetsova, Tatiana

AU - Balkestein, Elisabeth J.

AU - Struijker-Boudier, Harry A.

AU - Staessen, Jan A.

PY - 2011/1

Y1 - 2011/1

N2 - BACKGROUND Parathyroid hormone (PTH) and vitamin D interactively regulate calcium fluxes across membranes, and thereby modulate insulin sensitivity, blood pressure, and arterial calcification. We hypothesized that lower calcium intake as reflected by circulating PTH and 25-OH-D-3 might be associated with the metabolic syndrome (MS) and arterial calcification. METHODS In a random population sample (n = 542; 50.5% women; mean age, 49.8 +/- 13.1 years), we measured MS prevalence (International Diabetes Federation (IDF) and American Heart Association (AHA) criteria), PTH and 25-OH-D-3, serum and 24-h urinary calcium, MS components, carotid intima-media thickness (CIMT), and calcium intake from dairy products. We assessed associations in multivariable-adjusted analyses, using linear and logistic regressions. RESULTS The prevalence of MS was 21.0% (IDF criteria) and 23.6% (AHA criteria). MS prevalence, blood pressure, waist circumference, body mass index, fasting blood glucose, insulin and triglycerides, and CIMT increased (P

AB - BACKGROUND Parathyroid hormone (PTH) and vitamin D interactively regulate calcium fluxes across membranes, and thereby modulate insulin sensitivity, blood pressure, and arterial calcification. We hypothesized that lower calcium intake as reflected by circulating PTH and 25-OH-D-3 might be associated with the metabolic syndrome (MS) and arterial calcification. METHODS In a random population sample (n = 542; 50.5% women; mean age, 49.8 +/- 13.1 years), we measured MS prevalence (International Diabetes Federation (IDF) and American Heart Association (AHA) criteria), PTH and 25-OH-D-3, serum and 24-h urinary calcium, MS components, carotid intima-media thickness (CIMT), and calcium intake from dairy products. We assessed associations in multivariable-adjusted analyses, using linear and logistic regressions. RESULTS The prevalence of MS was 21.0% (IDF criteria) and 23.6% (AHA criteria). MS prevalence, blood pressure, waist circumference, body mass index, fasting blood glucose, insulin and triglycerides, and CIMT increased (P

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