TY - JOUR
T1 - The Metabolic Syndrome and Carotid Intima-Media Thickness in Relation to the Parathyroid Hormone to 25-OH-D-3 Ratio in a General Population
AU - Richart, Tom
AU - Thijs, Lutgarde
AU - Nawrot, Tim
AU - Yu, Jin
AU - Kuznetsova, Tatiana
AU - Balkestein, Elisabeth J.
AU - Struijker-Boudier, Harry A.
AU - Staessen, Jan A.
PY - 2011/1
Y1 - 2011/1
N2 - BACKGROUND Parathyroid hormone (PTH) and vitamin D interactively regulate calcium fluxes across membranes, and thereby modulate insulin sensitivity, blood pressure, and arterial calcification. We hypothesized that lower calcium intake as reflected by circulating PTH and 25-OH-D-3 might be associated with the metabolic syndrome (MS) and arterial calcification. METHODS In a random population sample (n = 542; 50.5% women; mean age, 49.8 +/- 13.1 years), we measured MS prevalence (International Diabetes Federation (IDF) and American Heart Association (AHA) criteria), PTH and 25-OH-D-3, serum and 24-h urinary calcium, MS components, carotid intima-media thickness (CIMT), and calcium intake from dairy products. We assessed associations in multivariable-adjusted analyses, using linear and logistic regressions. RESULTS The prevalence of MS was 21.0% (IDF criteria) and 23.6% (AHA criteria). MS prevalence, blood pressure, waist circumference, body mass index, fasting blood glucose, insulin and triglycerides, and CIMT increased (P
AB - BACKGROUND Parathyroid hormone (PTH) and vitamin D interactively regulate calcium fluxes across membranes, and thereby modulate insulin sensitivity, blood pressure, and arterial calcification. We hypothesized that lower calcium intake as reflected by circulating PTH and 25-OH-D-3 might be associated with the metabolic syndrome (MS) and arterial calcification. METHODS In a random population sample (n = 542; 50.5% women; mean age, 49.8 +/- 13.1 years), we measured MS prevalence (International Diabetes Federation (IDF) and American Heart Association (AHA) criteria), PTH and 25-OH-D-3, serum and 24-h urinary calcium, MS components, carotid intima-media thickness (CIMT), and calcium intake from dairy products. We assessed associations in multivariable-adjusted analyses, using linear and logistic regressions. RESULTS The prevalence of MS was 21.0% (IDF criteria) and 23.6% (AHA criteria). MS prevalence, blood pressure, waist circumference, body mass index, fasting blood glucose, insulin and triglycerides, and CIMT increased (P
KW - 25-OH-D-3
KW - blood pressure
KW - calcium
KW - hypertension
KW - insulin resistance
KW - intima-media thickness
KW - metabolic syndrome
KW - PTH
KW - vitamin D
U2 - 10.1038/ajh.2010.124
DO - 10.1038/ajh.2010.124
M3 - Article
C2 - 20596035
SN - 0895-7061
VL - 24
SP - 102
EP - 109
JO - American Journal of Hypertension
JF - American Journal of Hypertension
IS - 1
ER -