TY - JOUR
T1 - The LEAD (Lung, Heart, Social, Body) Study
T2 - Objectives, Methodology, and External Validity of the Population-Based Cohort Study
AU - Breyer-Kohansal, Robab
AU - Hartl, Sylvia
AU - Burghuber, Otto Chris
AU - Urban, Matthias
AU - Schrott, Andrea
AU - Agusti, Alvar
AU - Sigsgaard, Torben
AU - Vogelmeier, Claus
AU - Wouters, Emiel
AU - Studnicka, Michael
AU - Breyer, Marie-Kathrin
N1 - Funding Information:
This work was supported in part, by the Ludwig Boltzmann Society, Austrian Ministry of Health, Viennese hospital association, City of Vienna, and Medical University of Vienna.
Funding Information:
Authors thank all participants for their willingness to contribute to advanced medical science in the field of epidemiology, lung function development and decline. Special thanks to the whole LEAD study team, who worked every day for the high quality of the data obtained. Special thanks to Barbara W?gerbauer, who always stayed positive and optimistic and kept the team together for all the years. This work was supported in part, by the Ludwig Boltzmann Society, Austrian Ministry of Health, Viennese hospital association, City of Vienna, and Medical University of Vienna.
Publisher Copyright:
© 2018 Robab Breyer-Kohansal et al.
PY - 2019/8
Y1 - 2019/8
N2 - Background: The Lung, hEart, sociAl, boDy (LEAD) Study (ClinicalTrials.gov; NCT01727518; http://clinicaltrials.gov) is a longitudinal, observational, population-based Austrian cohort that aims to investigate the relationship between genetic, environmental, social, developmental and ageing factors influencing respiratory health and comorbidities through life. The general working hypothesis of LEAD is the interaction of these genetic, environmental and socioeconomic factors influences lung development and ageing, the risk of occurrence of several non-communicable diseases (respiratory, cardiovascular, metabolic and neurologic), as well as their phenotypic (ie, clinical) presentation.Methods: LEAD invited from 2011-2016 a random sample (stratified by age, gender, residential area) of Vienna inhabitants (urban cohort) and all the inhabitants of six villages from Lower Austria (rural cohort). Participants will be followed-up every four years. A number of investigations and measurements were obtained in each of the four domains of the study (Lung, hEart, sociAl, boDy) including data to screen for lung, cardiovascular and metabolic diseases, osteoporosis, and cognitive function. Blood and urine samples are stored in a biobank for future investigations.Results: A total of 11.423 males (47.6%) and females (52.4%), aged 6-80 years have been included in the cohort. Compared to governmental statistics, the external validity of LEAD with respect to age, gender, citizenship, and smoking status was high.Conclusions: In conclusion, the LEAD cohort has been established following high quality standards; it is representative of the Austrian population and offers a platform to understand lung development and ageing as a key mechanism of human health both in early and late adulthood.
AB - Background: The Lung, hEart, sociAl, boDy (LEAD) Study (ClinicalTrials.gov; NCT01727518; http://clinicaltrials.gov) is a longitudinal, observational, population-based Austrian cohort that aims to investigate the relationship between genetic, environmental, social, developmental and ageing factors influencing respiratory health and comorbidities through life. The general working hypothesis of LEAD is the interaction of these genetic, environmental and socioeconomic factors influences lung development and ageing, the risk of occurrence of several non-communicable diseases (respiratory, cardiovascular, metabolic and neurologic), as well as their phenotypic (ie, clinical) presentation.Methods: LEAD invited from 2011-2016 a random sample (stratified by age, gender, residential area) of Vienna inhabitants (urban cohort) and all the inhabitants of six villages from Lower Austria (rural cohort). Participants will be followed-up every four years. A number of investigations and measurements were obtained in each of the four domains of the study (Lung, hEart, sociAl, boDy) including data to screen for lung, cardiovascular and metabolic diseases, osteoporosis, and cognitive function. Blood and urine samples are stored in a biobank for future investigations.Results: A total of 11.423 males (47.6%) and females (52.4%), aged 6-80 years have been included in the cohort. Compared to governmental statistics, the external validity of LEAD with respect to age, gender, citizenship, and smoking status was high.Conclusions: In conclusion, the LEAD cohort has been established following high quality standards; it is representative of the Austrian population and offers a platform to understand lung development and ageing as a key mechanism of human health both in early and late adulthood.
KW - population based cohort
KW - epidemiology
KW - respiratory diseases
KW - OBSTRUCTIVE PULMONARY-DISEASE
KW - RESPIRATORY SYMPTOMS
KW - SOCIOECONOMIC-STATUS
KW - NATURAL-HISTORY
KW - SMOKE EXPOSURE
KW - COPD
KW - LIFE
KW - QUESTIONNAIRE
KW - PREVALENCE
KW - PREVENTION
U2 - 10.2188/jea.JE20180039
DO - 10.2188/jea.JE20180039
M3 - Article
C2 - 30344197
SN - 0917-5040
VL - 29
SP - 315
EP - 324
JO - Journal of Epidemiology
JF - Journal of Epidemiology
IS - 8
ER -