TY - JOUR
T1 - The integrative panel of fatty acid desaturase-2 (FADS2) rs174583 gene polymorphism and dietary indices (DQI-I and HEI) affects cardiovascular risk factors among obese individuals
AU - Mahmoudinezhad, M.
AU - Khosravaniardakani, S.
AU - Badelou, L.S.
AU - Fayyazishishavan, E.
AU - Kahroba, H.
AU - Farhangi, M.A.
N1 - Funding Information:
We thank all the study participants. We also thank Research Undersecretary of Tabriz University of Medical Sciences for their financial support (Grant number: 64111).
Funding Information:
This study was financially supported by a grant from Tabriz University of Medical Sciences, Iran (Identifiers: IR.TBZMED.REC.1399.062. and IR.TBZMED.REC.1398.460).
Publisher Copyright:
© 2023, The Author(s).
PY - 2023/2/15
Y1 - 2023/2/15
N2 - BackgroundRecent studies have shown that dietary intakes and gene variants have a critical role in the obesity related comorbidities. This study aimed to evaluate the effects of the interactions between Fatty acid desaturase 2 (FADS2) gene rs174583 polymorphism and two dietary indices on cardiometabolic risk factors.MethodsThis cross-sectional study was carried out on 347 obese adults aged 20-50 years old in Tabriz, Iran. Healthy eating index (HEI) and Diet quality index-international (DQI-I) were evaluated by a validated semi-quantitative 147-item Food frequency questionnaire (FFQ). Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to determine FADS2 gene variants. Multivariate analysis of covariance (MANCOVA) was used to identify gene-diet interactions on metabolic parameters.ResultsWaist circumference (WC) and serum triglyceride (TG) levels were significantly higher among carriers of TT genotype of FADS2 gene (P < 0.05). In addition, the interactions between FADS2 gene rs174583 polymorphism and DQI-I had significant effects on weight (P (interaction) = 0.01), fat mass (P (interaction) = 0.04), fat free mass (P (interaction) = 0.03), and Body mass index (BMI) (P (interaction) = 0.02); the highest level of these parameters belonged to TT carriers. Similarly, the interactions between FADS2 gene variants and HEI had significant effects on insulin (P (interaction) < 0.001), Homeostasis model assessment of insulin resistance (HOMA-IR) (P (interaction) < 0.001), Quantitative insulin check index (QUICKI) (P (interaction) = 0.001), and alpha Melanocyte stimulating hormone (alpha-MSH) (P (interaction) = 0.03).ConclusionIn this study, for the first time, we reported the effects of gene-diet interactions on metabolic traits. Compliance with dietary indices (DQI-I and HEI) ameliorated the adverse effects of gene variants on metabolic risk factors, especially in heterogeneous genotypes. Further prospective cohort studies are needed to confirm these results.
AB - BackgroundRecent studies have shown that dietary intakes and gene variants have a critical role in the obesity related comorbidities. This study aimed to evaluate the effects of the interactions between Fatty acid desaturase 2 (FADS2) gene rs174583 polymorphism and two dietary indices on cardiometabolic risk factors.MethodsThis cross-sectional study was carried out on 347 obese adults aged 20-50 years old in Tabriz, Iran. Healthy eating index (HEI) and Diet quality index-international (DQI-I) were evaluated by a validated semi-quantitative 147-item Food frequency questionnaire (FFQ). Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to determine FADS2 gene variants. Multivariate analysis of covariance (MANCOVA) was used to identify gene-diet interactions on metabolic parameters.ResultsWaist circumference (WC) and serum triglyceride (TG) levels were significantly higher among carriers of TT genotype of FADS2 gene (P < 0.05). In addition, the interactions between FADS2 gene rs174583 polymorphism and DQI-I had significant effects on weight (P (interaction) = 0.01), fat mass (P (interaction) = 0.04), fat free mass (P (interaction) = 0.03), and Body mass index (BMI) (P (interaction) = 0.02); the highest level of these parameters belonged to TT carriers. Similarly, the interactions between FADS2 gene variants and HEI had significant effects on insulin (P (interaction) < 0.001), Homeostasis model assessment of insulin resistance (HOMA-IR) (P (interaction) < 0.001), Quantitative insulin check index (QUICKI) (P (interaction) = 0.001), and alpha Melanocyte stimulating hormone (alpha-MSH) (P (interaction) = 0.03).ConclusionIn this study, for the first time, we reported the effects of gene-diet interactions on metabolic traits. Compliance with dietary indices (DQI-I and HEI) ameliorated the adverse effects of gene variants on metabolic risk factors, especially in heterogeneous genotypes. Further prospective cohort studies are needed to confirm these results.
KW - Fatty acid desaturase
KW - Diet quality index-international
KW - Healthy eating index
KW - Obesity
KW - INSULIN-RESISTANCE
KW - RELATIVE VALIDITY
KW - PHYSICAL-ACTIVITY
KW - QUALITY
KW - PLASMA
KW - REPRODUCIBILITY
KW - ASSOCIATION
KW - CHOLESTEROL
KW - CLUSTER
KW - LIFE
U2 - 10.1186/s12902-023-01289-3
DO - 10.1186/s12902-023-01289-3
M3 - Article
C2 - 36788508
SN - 1472-6823
VL - 23
JO - BMC Endocrine Disorders
JF - BMC Endocrine Disorders
IS - 1
M1 - 41
ER -