The inflamed liver: RAGE and Gluttony

Mitchell Bijnen

Research output: ThesisDoctoral ThesisInternal

388 Downloads (Pure)

Abstract

Non-alcoholic fatty liver (NAFLD) is a progressive liver disease that varies from fat accumulation to severe liver damage. The development of liver inflammation is an important step in the course of NAFLD, because it causes liver damage and increases the risk of arteriosclerosis. In this thesis, the two possible causes of liver inflammation and arteriosclerosis were analyzed: fatty tissue macrophages and saccharified proteins (AGEs) via their receptor, RAGE.
The conclusions of this thesis are:
-Fat tissue macrophages increase the number of immune cells in the blood by releasing inflammatory factors.
- Fatty tissue macrophages influence the degree of liver inflammation, but not atherosclerosis in the model used.
- Fatty liver and liver inflammation, yet also absorption from food contribute to AGE accumulation in the liver.
-AGEs can cause liver inflammation, but RAGE does not seem to play a role in liver inflammation or arteriosclerosis.
Original languageEnglish
Awarding Institution
  • Maastricht University
Supervisors/Advisors
  • Schalkwijk, Casper, Supervisor
  • Wouters, Kristiaan, Advisor
Award date22 Feb 2019
Place of PublicationMaastricht
Publisher
Print ISBNs9789463234894
DOIs
Publication statusPublished - 2019

Cite this