The human voice areas: Spatial organization and inter-individual variability in temporal and extra-temporal cortices

C.R. Pernet; P. McAleer; M. Latinus; K.J. Gorgolewski; I. Charest; P.E.G. Bestelmeyer; R.H. Watson; D. Fleming; F. Crabbe; M. Valdes-Sosa; P. Belin

doi:10.1016/j.neuroimage.2015.06.050

The human voice areas: Spatial organization and inter-individual variability in temporal and extra-temporal cortices

C.R. Pernet^*, P. McAleer, M. Latinus, K.J. Gorgolewski, I. Charest, P.E.G. Bestelmeyer, R.H. Watson, D. Fleming, F. Crabbe, M. Valdes-Sosa, P. Belin

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

fMRI studies increasingly examine functions and properties of non-primary areas of human auditory cortex. However there is currently no standardized localization procedure to reliably identify specific areas across individuals such as the standard 'localizers' available in the visual domain. Here we present an fMRI 'voice localizer' scan allowing rapid and reliable localization of the voice-sensitive 'temporal voice areas' (TVA) of human auditory cortex. We describe results obtained using this standardized localizer scan in a large cohort of normal adult subjects. Most participants (94%) showed bilateral patches of significantly greater response to vocal than nonvocal sounds along the superior temporal sulcus/gyrus (STS/STG). Individual activation patterns, although reproducible, showed high inter-individual variability in precise anatomical location. Cluster analysis of individual peaks from the large cohort highlighted three bilateral clusters of voice-sensitivity, or "voice patches" along posterior (TVAp), mid (TVAm) and anterior (TVAa) STS/STG, respectively. A series of extra-temporal areas including bilateral inferior prefrontal cortex and amygdalae showed small, but reliable voice-sensitivity as part of a large-scale cerebral voice network. Stimuli for the voice localizer scan and probabilistic maps in MNI space are available for download. Crown Copyright (C) 2015 Published by Elsevier Inc.

Original language	English
Pages (from-to)	164-174
Journal	Neuroimage
Volume	119
DOIs	https://doi.org/10.1016/j.neuroimage.2015.06.050
Publication status	Published - 1 Jan 2015

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Cite this

@article{b1e956ae952449ad8e0612bc826a0082,

title = "The human voice areas: Spatial organization and inter-individual variability in temporal and extra-temporal cortices",

abstract = "fMRI studies increasingly examine functions and properties of non-primary areas of human auditory cortex. However there is currently no standardized localization procedure to reliably identify specific areas across individuals such as the standard 'localizers' available in the visual domain. Here we present an fMRI 'voice localizer' scan allowing rapid and reliable localization of the voice-sensitive 'temporal voice areas' (TVA) of human auditory cortex. We describe results obtained using this standardized localizer scan in a large cohort of normal adult subjects. Most participants (94%) showed bilateral patches of significantly greater response to vocal than nonvocal sounds along the superior temporal sulcus/gyrus (STS/STG). Individual activation patterns, although reproducible, showed high inter-individual variability in precise anatomical location. Cluster analysis of individual peaks from the large cohort highlighted three bilateral clusters of voice-sensitivity, or {"}voice patches{"} along posterior (TVAp), mid (TVAm) and anterior (TVAa) STS/STG, respectively. A series of extra-temporal areas including bilateral inferior prefrontal cortex and amygdalae showed small, but reliable voice-sensitivity as part of a large-scale cerebral voice network. Stimuli for the voice localizer scan and probabilistic maps in MNI space are available for download. Crown Copyright (C) 2015 Published by Elsevier Inc.",

author = "C.R. Pernet and P. McAleer and M. Latinus and K.J. Gorgolewski and I. Charest and P.E.G. Bestelmeyer and R.H. Watson and D. Fleming and F. Crabbe and M. Valdes-Sosa and P. Belin",

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AU - Pernet, C.R.

AU - McAleer, P.

AU - Latinus, M.

AU - Gorgolewski, K.J.

AU - Charest, I.

AU - Bestelmeyer, P.E.G.

AU - Watson, R.H.

AU - Fleming, D.

AU - Crabbe, F.

AU - Valdes-Sosa, M.

AU - Belin, P.

PY - 2015/1/1

Y1 - 2015/1/1

N2 - fMRI studies increasingly examine functions and properties of non-primary areas of human auditory cortex. However there is currently no standardized localization procedure to reliably identify specific areas across individuals such as the standard 'localizers' available in the visual domain. Here we present an fMRI 'voice localizer' scan allowing rapid and reliable localization of the voice-sensitive 'temporal voice areas' (TVA) of human auditory cortex. We describe results obtained using this standardized localizer scan in a large cohort of normal adult subjects. Most participants (94%) showed bilateral patches of significantly greater response to vocal than nonvocal sounds along the superior temporal sulcus/gyrus (STS/STG). Individual activation patterns, although reproducible, showed high inter-individual variability in precise anatomical location. Cluster analysis of individual peaks from the large cohort highlighted three bilateral clusters of voice-sensitivity, or "voice patches" along posterior (TVAp), mid (TVAm) and anterior (TVAa) STS/STG, respectively. A series of extra-temporal areas including bilateral inferior prefrontal cortex and amygdalae showed small, but reliable voice-sensitivity as part of a large-scale cerebral voice network. Stimuli for the voice localizer scan and probabilistic maps in MNI space are available for download. Crown Copyright (C) 2015 Published by Elsevier Inc.

AB - fMRI studies increasingly examine functions and properties of non-primary areas of human auditory cortex. However there is currently no standardized localization procedure to reliably identify specific areas across individuals such as the standard 'localizers' available in the visual domain. Here we present an fMRI 'voice localizer' scan allowing rapid and reliable localization of the voice-sensitive 'temporal voice areas' (TVA) of human auditory cortex. We describe results obtained using this standardized localizer scan in a large cohort of normal adult subjects. Most participants (94%) showed bilateral patches of significantly greater response to vocal than nonvocal sounds along the superior temporal sulcus/gyrus (STS/STG). Individual activation patterns, although reproducible, showed high inter-individual variability in precise anatomical location. Cluster analysis of individual peaks from the large cohort highlighted three bilateral clusters of voice-sensitivity, or "voice patches" along posterior (TVAp), mid (TVAm) and anterior (TVAa) STS/STG, respectively. A series of extra-temporal areas including bilateral inferior prefrontal cortex and amygdalae showed small, but reliable voice-sensitivity as part of a large-scale cerebral voice network. Stimuli for the voice localizer scan and probabilistic maps in MNI space are available for download. Crown Copyright (C) 2015 Published by Elsevier Inc.

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DO - 10.1016/j.neuroimage.2015.06.050

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