The functional importance of the cellular and extracellular composition of the islets of Langerhans

Fredrik Wieland, Clemens van Blitterswijk, Aart van Apeldoorn, Vanessa LaPointe*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


The pancreatic islet of Langerhans is a multicellular system that relies on cell–cell interaction and communication for its function. The most abundant cells in the islets are alpha, beta and endothelial cells, all of which have been shown to positively support each other by generating direct cell–cell interactions, extracellular matrix proteins, or through the secretion of soluble factors into the extracellular space. Knowing how these cell types assemble and support each other to improve viability, migration, and function (glucose responsiveness) is important for the aim of re-establishing beta cell mass with a de novo cell source derived from human cells.
Original languageEnglish
Article number100048
Number of pages8
JournalJournal of Immunology and Regenerative Medicine
Publication statusPublished - 2021

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