The extracellular matrix in cardiovascular aging

Deolinda Santinha; Andreia Vilaça; Alessandro Ori; Lino Ferreira

doi:10.1016/B978-0-12-823761-8.00025-2

The extracellular matrix in cardiovascular aging

Deolinda Santinha, Andreia Vilaça, Alessandro Ori, Lino Ferreira

Research output: Chapter in Book/Report/Conference proceeding › Chapter › Academic

Abstract

“In this chapter, we cover the alterations of the heart ECM during aging. The expression and properties of collagens, elastin, matricellular proteins, glycosaminoglycans and proteoglycans, adhesive proteins and basement membrane components will be discussed and compared between young and aged hearts. The remodeling of ECM in aged individuals, in the context of myocardial infarction and heart failure, will also be discussed as well as future directions in the research area of ECM and cardiovascular aging”.

Original language	English
Title of host publication	Aging: From Fundamental Biology to Societal Impact
Editors	Paulo J. Oliveira, João O. Malva
Publisher	Elsevier
Pages	523-545
Number of pages	23
ISBN (Electronic)	9780128237618
ISBN (Print)	9780128241318
DOIs	https://doi.org/10.1016/B978-0-12-823761-8.00025-2
Publication status	Published - 1 Jan 2022

Keywords

aging
Cardiac pathologies
cardiovascular diseases
elderly
heart failure

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10.1016/B978-0-12-823761-8.00025-2

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title = "The extracellular matrix in cardiovascular aging",

abstract = "“In this chapter, we cover the alterations of the heart ECM during aging. The expression and properties of collagens, elastin, matricellular proteins, glycosaminoglycans and proteoglycans, adhesive proteins and basement membrane components will be discussed and compared between young and aged hearts. The remodeling of ECM in aged individuals, in the context of myocardial infarction and heart failure, will also be discussed as well as future directions in the research area of ECM and cardiovascular aging”.",

keywords = "aging, Cardiac pathologies, cardiovascular diseases, elderly, heart failure",

author = "Deolinda Santinha and Andreia Vila{\c c}a and Alessandro Ori and Lino Ferreira",

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T1 - The extracellular matrix in cardiovascular aging

AU - Santinha, Deolinda

AU - Vilaça, Andreia

AU - Ori, Alessandro

AU - Ferreira, Lino

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N2 - “In this chapter, we cover the alterations of the heart ECM during aging. The expression and properties of collagens, elastin, matricellular proteins, glycosaminoglycans and proteoglycans, adhesive proteins and basement membrane components will be discussed and compared between young and aged hearts. The remodeling of ECM in aged individuals, in the context of myocardial infarction and heart failure, will also be discussed as well as future directions in the research area of ECM and cardiovascular aging”.

AB - “In this chapter, we cover the alterations of the heart ECM during aging. The expression and properties of collagens, elastin, matricellular proteins, glycosaminoglycans and proteoglycans, adhesive proteins and basement membrane components will be discussed and compared between young and aged hearts. The remodeling of ECM in aged individuals, in the context of myocardial infarction and heart failure, will also be discussed as well as future directions in the research area of ECM and cardiovascular aging”.

KW - aging

KW - Cardiac pathologies

KW - cardiovascular diseases

KW - elderly

KW - heart failure

U2 - 10.1016/B978-0-12-823761-8.00025-2

DO - 10.1016/B978-0-12-823761-8.00025-2

M3 - Chapter

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BT - Aging: From Fundamental Biology to Societal Impact

A2 - Oliveira, Paulo J.

A2 - Malva, João O.

PB - Elsevier

ER -

The extracellular matrix in cardiovascular aging

Abstract

Keywords

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