The evaluation of the two-stage prothrombin assay

H.C. Hemker; P.W. Hemker; K. v.d. Torren; P.P. Devilee; W. Th. Hermens; E.A. Loeliger

doi:10.1055/S-0038-1654328

The evaluation of the two-stage prothrombin assay

H.C. Hemker, P.W. Hemker, K. v.d. Torren, P.P. Devilee, W. Th. Hermens, E.A. Loeliger

Research output: Contribution to journal › Article › Academic › peer-review

143 Downloads (Pure)

Abstract

It is shown that (and why) the traditional ways of evaluating a thrombin generation curve do not give acceptable estimations of the prothrombin content of the sample. An alternative method is shown to meet the requirements better; it consists of drawing the thrombin generation curve on a semi-logarithmic graph, and extrapolating the descending slope to zero time. This gives a thrombin concentration representing the prothrombin concentration of the original sample.

Original language	English
Pages (from-to)	545-554
Number of pages	10
Journal	Thrombosis et diathesis haemorrhagica
Volume	25
Issue number	3
DOIs	https://doi.org/10.1055/S-0038-1654328
Publication status	Published - 1 Jan 1971

Access to Document

10.1055/S-0038-1654328

Full TextOther version, 6.12 MB

Cite this

@article{20dbbc18fea4450f87e5642ed41660cd,

title = "The evaluation of the two-stage prothrombin assay",

abstract = "It is shown that (and why) the traditional ways of evaluating a thrombin generation curve do not give acceptable estimations of the prothrombin content of the sample. An alternative method is shown to meet the requirements better; it consists of drawing the thrombin generation curve on a semi-logarithmic graph, and extrapolating the descending slope to zero time. This gives a thrombin concentration representing the prothrombin concentration of the original sample.",

author = "H.C. Hemker and P.W. Hemker and {v.d. Torren}, K. and P.P. Devilee and Hermens, {W. Th.} and E.A. Loeliger",

year = "1971",

month = jan,

day = "1",

doi = "10.1055/S-0038-1654328",

language = "English",

volume = "25",

pages = "545--554",

journal = "Thrombosis et diathesis haemorrhagica",

issn = "0340-5338",

publisher = "F. K. Schattauer Verlag",

number = "3",

}

TY - JOUR

T1 - The evaluation of the two-stage prothrombin assay

AU - Hemker, H.C.

AU - Hemker, P.W.

AU - v.d. Torren, K.

AU - Devilee, P.P.

AU - Hermens, W. Th.

AU - Loeliger, E.A.

PY - 1971/1/1

Y1 - 1971/1/1

N2 - It is shown that (and why) the traditional ways of evaluating a thrombin generation curve do not give acceptable estimations of the prothrombin content of the sample. An alternative method is shown to meet the requirements better; it consists of drawing the thrombin generation curve on a semi-logarithmic graph, and extrapolating the descending slope to zero time. This gives a thrombin concentration representing the prothrombin concentration of the original sample.

AB - It is shown that (and why) the traditional ways of evaluating a thrombin generation curve do not give acceptable estimations of the prothrombin content of the sample. An alternative method is shown to meet the requirements better; it consists of drawing the thrombin generation curve on a semi-logarithmic graph, and extrapolating the descending slope to zero time. This gives a thrombin concentration representing the prothrombin concentration of the original sample.

U2 - 10.1055/S-0038-1654328

DO - 10.1055/S-0038-1654328

M3 - Article

SN - 0340-5338

VL - 25

SP - 545

EP - 554

JO - Thrombosis et diathesis haemorrhagica

JF - Thrombosis et diathesis haemorrhagica

IS - 3

ER -

The evaluation of the two-stage prothrombin assay

Abstract

Access to Document

Fingerprint

Cite this