The evaluation of the two-stage prothrombin assay

H.C. Hemker; P.W. Hemker; K. v.d. Torren; P.P. Devilee; W. Th. Hermens; E.A. Loeliger

doi:10.1055/S-0038-1654328

The evaluation of the two-stage prothrombin assay

H.C. Hemker, P.W. Hemker, K. v.d. Torren, P.P. Devilee, W. Th. Hermens, E.A. Loeliger

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Abstract

It is shown that (and why) the traditional ways of evaluating a thrombin generation curve do not give acceptable estimations of the prothrombin content of the sample. An alternative method is shown to meet the requirements better; it consists of drawing the thrombin generation curve on a semi-logarithmic graph, and extrapolating the descending slope to zero time. This gives a thrombin concentration representing the prothrombin concentration of the original sample.

Original language	English
Pages (from-to)	545-554
Number of pages	10
Journal	Thrombosis et diathesis haemorrhagica
Volume	25
Issue number	3
DOIs	https://doi.org/10.1055/S-0038-1654328
Publication status	Published - 1 Jan 1971

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title = "The evaluation of the two-stage prothrombin assay",

abstract = "It is shown that (and why) the traditional ways of evaluating a thrombin generation curve do not give acceptable estimations of the prothrombin content of the sample. An alternative method is shown to meet the requirements better; it consists of drawing the thrombin generation curve on a semi-logarithmic graph, and extrapolating the descending slope to zero time. This gives a thrombin concentration representing the prothrombin concentration of the original sample.",

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AU - Loeliger, E.A.

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AB - It is shown that (and why) the traditional ways of evaluating a thrombin generation curve do not give acceptable estimations of the prothrombin content of the sample. An alternative method is shown to meet the requirements better; it consists of drawing the thrombin generation curve on a semi-logarithmic graph, and extrapolating the descending slope to zero time. This gives a thrombin concentration representing the prothrombin concentration of the original sample.

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