The epidemiology of mescaline use: Pattern of use, motivations for consumption, and perceived consequences, benefits, and acute and enduring subjective effects

Malin Vedoy Uthaug*, Alan K. Davis, Trevor Forrest Haas, Dawn Davis, Sean B. Dolan, Rafael Lancelotta, Christopher Timmermann, Johannes G. Ramaekers*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

10 Citations (Web of Science)

Abstract

Background:

Mescaline is a naturally occurring psychoactive phenethylamine found in several cacti and historically used ceremonially by Indigenous and Latin American populations. Broader recognition of its possible therapeutic value in Western science began in the 1950s; however, knowledge of the safety profile of mescaline and the extent of its use remains limited. The primary aim of this study is to examine the epidemiology of mescaline use among English-speaking adults.

Methods:

About 452 respondents completed a web-based survey designed to assess their previous experience with mescaline (subjective effects, outcome measures, and mescaline type used).

Results:

Most respondents reported that they had consumed mescaline infrequently (67%) reported improvements in these conditions following their most memorable experience with mescaline.

Conclusion:

Findings indicate that the mescaline in any form may produce a psychedelic experience that is associated with the spiritual significance and improvements in the mental health with low potential for abuse.

Original languageEnglish
Pages (from-to)309-320
Number of pages12
JournalJournal of Psychopharmacology
Volume36
Issue number3
Early online date5 May 2021
DOIs
Publication statusPublished - Mar 2022

Keywords

  • Mescaline
  • 3
  • 4
  • 5-trimethoxyphenethylamine
  • epidemiology
  • survey
  • RECEPTOR INTERACTION PROFILES
  • LYSERGIC-ACID DIETHYLAMIDE
  • EXPERIENCE QUESTIONNAIRE
  • PEYOTE USE
  • HALLUCINOGENS
  • PSILOCYBIN
  • PSYCHEDELICS
  • PERSONALITY
  • BEHAVIOR

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