The effects of polyphenol supplementation on adipose tissue morphology and gene expression in overweight and obese humans

Jasper Most, Ines Warnke, Mark V. Boekschoten, Johan W. E. Jocken, Philip de Groot, Angelika Friedel, Igor Bendik, Gijs H. Goossens, Ellen E. Blaak*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

21 Citations (Web of Science)

Abstract

Dietary polyphenols have beneficial effects on adipose tissue mass and function in rodents, but human studies are scarce. In a randomized, placebo-controlled study, 25 (10 women) overweight and obese humans received a combination of the polyphenols epigallocatechin-gallate and resveratrol (282mg/d, 80mg/d, respectively, EGCG+RES, n = 11) or placebo (PLA, n = 14) supplementation for 12weeks. Abdominal subcutaneous adipose tissue (SAT) biopsies were collected for assessment of adipocyte morphology and micro-array analysis. EGCG+RES had no effects on adipocyte size and distribution compared with PLA. However, we identified pathways contributing to adipogenesis, cell cycle and apoptosis were significantly downregulated by EGCG+RES versus PLA. Furthermore, EGCG+RES significantly decreased expression of pathways related to energy metabolism, oxidative stress, inflammation, and immune defense as compared with PLA. In conclusion, the SAT gene expression profile indicates a reduced cell turnover after 12-week EGCG+RES in overweight-obese subjects. It remains to be elucidated whether these alterations translate into long-term metabolic effects.
Original languageEnglish
Pages (from-to)190-196
Number of pages7
JournalAdipocyte
Volume7
Issue number3
DOIs
Publication statusPublished - 1 Jan 2018

Keywords

  • Adipose tissue
  • EGCG
  • Morphology
  • Obesity
  • Resveratrol
  • Transcriptomics
  • RESVERATROL SUPPLEMENTATION
  • INSULIN-RESISTANCE
  • METABOLIC DISEASE
  • TURNOVER
  • EPIGALLOCATECHIN-3-GALLATE
  • MECHANISMS
  • WEIGHT
  • WOMEN
  • TRIAL
  • MICE

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