The effects of acute exercise and high lactate levels on 35% CO2 challenge in healthy volunteers

G. Esquivel, K.R.J. Schruers, H. Kuipers, E.J.L. Griez*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Department of Psychiatry and Neuropsychology and Academic Anxiety Center, Maastricht University, Maastricht, The Netherlands.

OBJECTIVE: To test the possible antipanic effects of acute exercise in healthy volunteers exposed to an inhalation of 35% CO2 challenge. METHOD: Twenty healthy subjects in a randomized separate group design, performed exercise in a bicycle ergometer reaching >6 mm of blood lactate and a control condition of minimal activity in the same fashion with no lactate elevation. Immediately afterwards an inhalation of a vital capacity using a mixture of 35% CO2/65% O2 through a mask was given on both conditions. RESULTS: Subjects under the exercise condition reported less panic symptoms than controls after a CO2 challenge on the diagnostic statistical manual-IV (DSM-IV) Panic Symptom List but no difference on the Visual Analogue Anxiety Scale. CONCLUSION: Subjects under the exertion condition had lactate levels comparable with those of lactate infusions but an inhibitory rather than accumulative effect was seen when combined with a CO2 challenge.
Original languageEnglish
Pages (from-to)394-397
Number of pages4
JournalActa Psychiatrica Scandinavica
Issue number5
Publication statusPublished - 1 Jan 2002

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