The effect of weight loss on whole-body and tissue-specific insulin sensitivity and hepatic lipid content and composition: SWEET substudy

Michelle D. Pang; Jacco J. A. J. Bastings; Yvonne M. H. Op den Kamp-Bruls; Joanne A. Harrold; Louise Kjolbaek; Jason C. G. Halford; Tanja C. M. Adam; Anne Raben; Vera B. Schrauwen-Hinderling; Gijs H. Goossens; Ellen E. Blaak

doi:10.1002/oby.23773

The effect of weight loss on whole-body and tissue-specific insulin sensitivity and hepatic lipid content and composition: SWEET substudy

Michelle D. Pang, Jacco J. A. J. Bastings, Yvonne M. H. Op den Kamp-Bruls, Joanne A. Harrold, Louise Kjolbaek, Jason C. G. Halford, Tanja C. M. Adam, Anne Raben, Vera B. Schrauwen-Hinderling, Gijs H. Goossens, Ellen E. Blaak^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

ObjectiveThis study (1) investigated the effect of weight loss on whole-body and tissue-specific insulin sensitivity and on intrahepatic lipid (IHL) content and composition and (2) investigated the association between weight-loss-induced changes in insulin sensitivity and IHL content in individuals with overweight or obesity. MethodsIn this secondary analysis of the European SWEET project, 50 adults (age 18-65 years) with overweight or obesity (BMI & GE; 25 kg/m(2)) followed a low-energy diet (LED) for 2 months. At baseline and after the LED, body composition (dual-energy x-ray absorptiometry), IHL content and composition (proton magnetic resonance spectroscopy), whole-body insulin sensitivity (Matsuda index), muscle insulin sensitivity index (MISI), and hepatic insulin resistance index (HIRI) were determined (7-point oral glucose tolerance test). ResultsThe LED reduced body weight (p < 0.001). This was accompanied by increased Matsuda index and reduced HIRI (both p < 0.001) but no change in MISI (p = 0.260). Weight loss decreased IHL content (mean [SEM], 3.9% [0.7%] vs. 1.6% [0.5%], p < 0.001) and the hepatic saturated fatty acid fraction (41.0% [1.5%] vs. 36.6% [1.9%], p = 0.039). The reduced IHL content was associated with an improvement in HIRI (r = 0.402, p = 0.025). ConclusionsWeight loss decreased IHL content and the hepatic saturated fatty acid fraction. The decrease in IHL content was associated with weight-loss-induced improvement in hepatic insulin sensitivity in individuals with overweight or obesity.

Original language	English
Pages (from-to)	1745-1754
Number of pages	10
Journal	Obesity
Volume	31
Issue number	7
DOIs	https://doi.org/10.1002/oby.23773
Publication status	Published - 1 Jul 2023

Keywords

LIVER FAT
OBESE WOMEN
RESISTANCE
MUSCLE
STEATOSIS

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Pang, M. D., Bastings, J. J. A. J., Op den Kamp-Bruls, Y. M. H., Harrold, J. A., Kjolbaek, L., Halford, J. C. G., Adam, T. C. M., Raben, A., Schrauwen-Hinderling, V. B., Goossens, G. H., & Blaak, E. E. (2023). The effect of weight loss on whole-body and tissue-specific insulin sensitivity and hepatic lipid content and composition: SWEET substudy. Obesity, 31(7), 1745-1754. https://doi.org/10.1002/oby.23773

@article{3dc690598a9444c2bddc0c9038df1997,

title = "The effect of weight loss on whole-body and tissue-specific insulin sensitivity and hepatic lipid content and composition: SWEET substudy",

abstract = "ObjectiveThis study (1) investigated the effect of weight loss on whole-body and tissue-specific insulin sensitivity and on intrahepatic lipid (IHL) content and composition and (2) investigated the association between weight-loss-induced changes in insulin sensitivity and IHL content in individuals with overweight or obesity. MethodsIn this secondary analysis of the European SWEET project, 50 adults (age 18-65 years) with overweight or obesity (BMI & GE; 25 kg/m(2)) followed a low-energy diet (LED) for 2 months. At baseline and after the LED, body composition (dual-energy x-ray absorptiometry), IHL content and composition (proton magnetic resonance spectroscopy), whole-body insulin sensitivity (Matsuda index), muscle insulin sensitivity index (MISI), and hepatic insulin resistance index (HIRI) were determined (7-point oral glucose tolerance test). ResultsThe LED reduced body weight (p < 0.001). This was accompanied by increased Matsuda index and reduced HIRI (both p < 0.001) but no change in MISI (p = 0.260). Weight loss decreased IHL content (mean [SEM], 3.9% [0.7%] vs. 1.6% [0.5%], p < 0.001) and the hepatic saturated fatty acid fraction (41.0% [1.5%] vs. 36.6% [1.9%], p = 0.039). The reduced IHL content was associated with an improvement in HIRI (r = 0.402, p = 0.025). ConclusionsWeight loss decreased IHL content and the hepatic saturated fatty acid fraction. The decrease in IHL content was associated with weight-loss-induced improvement in hepatic insulin sensitivity in individuals with overweight or obesity.",

keywords = "LIVER FAT, OBESE WOMEN, RESISTANCE, MUSCLE, STEATOSIS",

author = "Pang, {Michelle D.} and Bastings, {Jacco J. A. J.} and {Op den Kamp-Bruls}, {Yvonne M. H.} and Harrold, {Joanne A.} and Louise Kjolbaek and Halford, {Jason C. G.} and Adam, {Tanja C. M.} and Anne Raben and Schrauwen-Hinderling, {Vera B.} and Goossens, {Gijs H.} and Blaak, {Ellen E.}",

year = "2023",

month = jul,

day = "1",

doi = "10.1002/oby.23773",

language = "English",

volume = "31",

pages = "1745--1754",

journal = "Obesity",

issn = "1930-7381",

publisher = "Wiley",

number = "7",

}

Pang, MD , Bastings, JJAJ , Op den Kamp-Bruls, YMH, Harrold, JA, Kjolbaek, L, Halford, JCG, Adam, TCM, Raben, A, Schrauwen-Hinderling, VB , Goossens, GH & Blaak, EE 2023, 'The effect of weight loss on whole-body and tissue-specific insulin sensitivity and hepatic lipid content and composition: SWEET substudy', Obesity, vol. 31, no. 7, pp. 1745-1754. https://doi.org/10.1002/oby.23773

TY - JOUR

T1 - The effect of weight loss on whole-body and tissue-specific insulin sensitivity and hepatic lipid content and composition

T2 - SWEET substudy

AU - Pang, Michelle D.

AU - Bastings, Jacco J. A. J.

AU - Op den Kamp-Bruls, Yvonne M. H.

AU - Harrold, Joanne A.

AU - Kjolbaek, Louise

AU - Halford, Jason C. G.

AU - Adam, Tanja C. M.

AU - Raben, Anne

AU - Schrauwen-Hinderling, Vera B.

AU - Goossens, Gijs H.

AU - Blaak, Ellen E.

PY - 2023/7/1

Y1 - 2023/7/1

N2 - ObjectiveThis study (1) investigated the effect of weight loss on whole-body and tissue-specific insulin sensitivity and on intrahepatic lipid (IHL) content and composition and (2) investigated the association between weight-loss-induced changes in insulin sensitivity and IHL content in individuals with overweight or obesity. MethodsIn this secondary analysis of the European SWEET project, 50 adults (age 18-65 years) with overweight or obesity (BMI & GE; 25 kg/m(2)) followed a low-energy diet (LED) for 2 months. At baseline and after the LED, body composition (dual-energy x-ray absorptiometry), IHL content and composition (proton magnetic resonance spectroscopy), whole-body insulin sensitivity (Matsuda index), muscle insulin sensitivity index (MISI), and hepatic insulin resistance index (HIRI) were determined (7-point oral glucose tolerance test). ResultsThe LED reduced body weight (p < 0.001). This was accompanied by increased Matsuda index and reduced HIRI (both p < 0.001) but no change in MISI (p = 0.260). Weight loss decreased IHL content (mean [SEM], 3.9% [0.7%] vs. 1.6% [0.5%], p < 0.001) and the hepatic saturated fatty acid fraction (41.0% [1.5%] vs. 36.6% [1.9%], p = 0.039). The reduced IHL content was associated with an improvement in HIRI (r = 0.402, p = 0.025). ConclusionsWeight loss decreased IHL content and the hepatic saturated fatty acid fraction. The decrease in IHL content was associated with weight-loss-induced improvement in hepatic insulin sensitivity in individuals with overweight or obesity.

AB - ObjectiveThis study (1) investigated the effect of weight loss on whole-body and tissue-specific insulin sensitivity and on intrahepatic lipid (IHL) content and composition and (2) investigated the association between weight-loss-induced changes in insulin sensitivity and IHL content in individuals with overweight or obesity. MethodsIn this secondary analysis of the European SWEET project, 50 adults (age 18-65 years) with overweight or obesity (BMI & GE; 25 kg/m(2)) followed a low-energy diet (LED) for 2 months. At baseline and after the LED, body composition (dual-energy x-ray absorptiometry), IHL content and composition (proton magnetic resonance spectroscopy), whole-body insulin sensitivity (Matsuda index), muscle insulin sensitivity index (MISI), and hepatic insulin resistance index (HIRI) were determined (7-point oral glucose tolerance test). ResultsThe LED reduced body weight (p < 0.001). This was accompanied by increased Matsuda index and reduced HIRI (both p < 0.001) but no change in MISI (p = 0.260). Weight loss decreased IHL content (mean [SEM], 3.9% [0.7%] vs. 1.6% [0.5%], p < 0.001) and the hepatic saturated fatty acid fraction (41.0% [1.5%] vs. 36.6% [1.9%], p = 0.039). The reduced IHL content was associated with an improvement in HIRI (r = 0.402, p = 0.025). ConclusionsWeight loss decreased IHL content and the hepatic saturated fatty acid fraction. The decrease in IHL content was associated with weight-loss-induced improvement in hepatic insulin sensitivity in individuals with overweight or obesity.

KW - LIVER FAT

KW - OBESE WOMEN

KW - RESISTANCE

KW - MUSCLE

KW - STEATOSIS

U2 - 10.1002/oby.23773

DO - 10.1002/oby.23773

M3 - Article

C2 - 37368517

SN - 1930-7381

VL - 31

SP - 1745

EP - 1754

JO - Obesity

JF - Obesity

IS - 7

ER -