The effect of embryonic genome imbalances on pregnancy

Masoud Zamani Esteki

doi:10.1038/s41591-023-02687-9

The effect of embryonic genome imbalances on pregnancy

Masoud Zamani Esteki^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

The prevalence of aneuploid cells in miscarried human embryos is higher than previously quoted. Genomic imbalances seem to be less tolerated in the embryoblast than the trophoblast, which indicates that allocation of aneuploid cells to the inner cell mass during blastocyst formation might have a detrimental effect on embryo development.

Original language	English
Pages (from-to)	3014-3015
Number of pages	2
Journal	Nature Medicine
Volume	29
Issue number	12
DOIs	https://doi.org/10.1038/s41591-023-02687-9
Publication status	Published - Dec 2023

Access to Document

10.1038/s41591-023-02687-9

Cite this

@article{cce0ed58b018429cb5aa0f6b82a7537a,

title = "The effect of embryonic genome imbalances on pregnancy",

abstract = "The prevalence of aneuploid cells in miscarried human embryos is higher than previously quoted. Genomic imbalances seem to be less tolerated in the embryoblast than the trophoblast, which indicates that allocation of aneuploid cells to the inner cell mass during blastocyst formation might have a detrimental effect on embryo development.",

author = "{Zamani Esteki}, Masoud",

year = "2023",

month = dec,

doi = "10.1038/s41591-023-02687-9",

language = "English",

volume = "29",

pages = "3014--3015",

journal = "Nature Medicine",

issn = "1078-8956",

publisher = "Nature Publishing Group",

number = "12",

}

TY - JOUR

T1 - The effect of embryonic genome imbalances on pregnancy

AU - Zamani Esteki, Masoud

PY - 2023/12

Y1 - 2023/12

N2 - The prevalence of aneuploid cells in miscarried human embryos is higher than previously quoted. Genomic imbalances seem to be less tolerated in the embryoblast than the trophoblast, which indicates that allocation of aneuploid cells to the inner cell mass during blastocyst formation might have a detrimental effect on embryo development.

AB - The prevalence of aneuploid cells in miscarried human embryos is higher than previously quoted. Genomic imbalances seem to be less tolerated in the embryoblast than the trophoblast, which indicates that allocation of aneuploid cells to the inner cell mass during blastocyst formation might have a detrimental effect on embryo development.

U2 - 10.1038/s41591-023-02687-9

DO - 10.1038/s41591-023-02687-9

M3 - Article

SN - 1078-8956

VL - 29

SP - 3014

EP - 3015

JO - Nature Medicine

JF - Nature Medicine

IS - 12

ER -