The effect of Amaranth oil on monolayers of artificial lipids and hepatocyte plasma membranes with adrenalin-induced stress

O.P. Yelisyeyeva, K.O. Semen, G.V. Ostrovska, D.V. Kaminskyy, T.V. Sirota, N. Zarkovic, D. Mazur, O.D. Lutsyk, K. Rybalchenko, A. Bast

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)

Abstract

In this paper the oil from seeds of Amaranthus cruentus L. (AmO) was shown to be an efficient modulator of the physical chemical properties of artificial lipid and rat hepatocyte plasma membranes. AmO improved the membrane stability, their stress resistance and the adsorption of neurotensin to plasma membranes with the distinct biphasic interactions being observed even after adrenalin stress exposure. The analysis of pro-/antioxidant balance in rat blood revealed a mild prooxidant activity after AmO intake, which was accompanied by accumulation of oxidative destruction products in plasma membranes. This prooxidant action of AmO was corroborated in vitro in an adrenalin autooxidation model. On the other hand, the observed improved resistance to adrenalin stress in AmO supplemented rats was associated with an antioxidant response in blood and plasma membrane studies. The AmO effects can be attributed to the modulation of the metabolic pathways involved into oxygen and free radical homeostasis.
Original languageEnglish
Pages (from-to)152-159
Number of pages8
JournalFood Chemistry
Volume147
DOIs
Publication statusPublished - 15 Mar 2014

Keywords

  • Membrane monolayer
  • Amaranth oil
  • Neurotensin
  • Adrenalin-induced stress
  • Oxidative stress correction
  • Hormetic response
  • Adaptive stress response
  • Rats
  • OXIDIZED PHOSPHOLIPIDS
  • DISEASE
  • PEROXIDATION
  • NEUROTENSIN

Cite this

Yelisyeyeva, O.P. ; Semen, K.O. ; Ostrovska, G.V. ; Kaminskyy, D.V. ; Sirota, T.V. ; Zarkovic, N. ; Mazur, D. ; Lutsyk, O.D. ; Rybalchenko, K. ; Bast, A. / The effect of Amaranth oil on monolayers of artificial lipids and hepatocyte plasma membranes with adrenalin-induced stress. In: Food Chemistry. 2014 ; Vol. 147. pp. 152-159.
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abstract = "In this paper the oil from seeds of Amaranthus cruentus L. (AmO) was shown to be an efficient modulator of the physical chemical properties of artificial lipid and rat hepatocyte plasma membranes. AmO improved the membrane stability, their stress resistance and the adsorption of neurotensin to plasma membranes with the distinct biphasic interactions being observed even after adrenalin stress exposure. The analysis of pro-/antioxidant balance in rat blood revealed a mild prooxidant activity after AmO intake, which was accompanied by accumulation of oxidative destruction products in plasma membranes. This prooxidant action of AmO was corroborated in vitro in an adrenalin autooxidation model. On the other hand, the observed improved resistance to adrenalin stress in AmO supplemented rats was associated with an antioxidant response in blood and plasma membrane studies. The AmO effects can be attributed to the modulation of the metabolic pathways involved into oxygen and free radical homeostasis.",
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author = "O.P. Yelisyeyeva and K.O. Semen and G.V. Ostrovska and D.V. Kaminskyy and T.V. Sirota and N. Zarkovic and D. Mazur and O.D. Lutsyk and K. Rybalchenko and A. Bast",
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Yelisyeyeva, OP, Semen, KO, Ostrovska, GV, Kaminskyy, DV, Sirota, TV, Zarkovic, N, Mazur, D, Lutsyk, OD, Rybalchenko, K & Bast, A 2014, 'The effect of Amaranth oil on monolayers of artificial lipids and hepatocyte plasma membranes with adrenalin-induced stress', Food Chemistry, vol. 147, pp. 152-159. https://doi.org/10.1016/j.foodchem.2013.09.119

The effect of Amaranth oil on monolayers of artificial lipids and hepatocyte plasma membranes with adrenalin-induced stress. / Yelisyeyeva, O.P.; Semen, K.O.; Ostrovska, G.V.; Kaminskyy, D.V.; Sirota, T.V.; Zarkovic, N.; Mazur, D.; Lutsyk, O.D.; Rybalchenko, K.; Bast, A.

In: Food Chemistry, Vol. 147, 15.03.2014, p. 152-159.

Research output: Contribution to journalArticleAcademicpeer-review

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T1 - The effect of Amaranth oil on monolayers of artificial lipids and hepatocyte plasma membranes with adrenalin-induced stress

AU - Yelisyeyeva, O.P.

AU - Semen, K.O.

AU - Ostrovska, G.V.

AU - Kaminskyy, D.V.

AU - Sirota, T.V.

AU - Zarkovic, N.

AU - Mazur, D.

AU - Lutsyk, O.D.

AU - Rybalchenko, K.

AU - Bast, A.

PY - 2014/3/15

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N2 - In this paper the oil from seeds of Amaranthus cruentus L. (AmO) was shown to be an efficient modulator of the physical chemical properties of artificial lipid and rat hepatocyte plasma membranes. AmO improved the membrane stability, their stress resistance and the adsorption of neurotensin to plasma membranes with the distinct biphasic interactions being observed even after adrenalin stress exposure. The analysis of pro-/antioxidant balance in rat blood revealed a mild prooxidant activity after AmO intake, which was accompanied by accumulation of oxidative destruction products in plasma membranes. This prooxidant action of AmO was corroborated in vitro in an adrenalin autooxidation model. On the other hand, the observed improved resistance to adrenalin stress in AmO supplemented rats was associated with an antioxidant response in blood and plasma membrane studies. The AmO effects can be attributed to the modulation of the metabolic pathways involved into oxygen and free radical homeostasis.

AB - In this paper the oil from seeds of Amaranthus cruentus L. (AmO) was shown to be an efficient modulator of the physical chemical properties of artificial lipid and rat hepatocyte plasma membranes. AmO improved the membrane stability, their stress resistance and the adsorption of neurotensin to plasma membranes with the distinct biphasic interactions being observed even after adrenalin stress exposure. The analysis of pro-/antioxidant balance in rat blood revealed a mild prooxidant activity after AmO intake, which was accompanied by accumulation of oxidative destruction products in plasma membranes. This prooxidant action of AmO was corroborated in vitro in an adrenalin autooxidation model. On the other hand, the observed improved resistance to adrenalin stress in AmO supplemented rats was associated with an antioxidant response in blood and plasma membrane studies. The AmO effects can be attributed to the modulation of the metabolic pathways involved into oxygen and free radical homeostasis.

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KW - Oxidative stress correction

KW - Hormetic response

KW - Adaptive stress response

KW - Rats

KW - OXIDIZED PHOSPHOLIPIDS

KW - DISEASE

KW - PEROXIDATION

KW - NEUROTENSIN

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M3 - Article

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EP - 159

JO - Food Chemistry

JF - Food Chemistry

SN - 0308-8146

ER -