The effect of age on outcome after intraarterial treatment in acute ischemic stroke: a MR CLEAN pretrial study

Debbie Beumer; Anouk D. Rozeman; Geert J. Lycklama a Nijeholt; Patrick A. Brouwer; Sjoerd F. M. Jenniskens; Ale Algra; Jelis Boiten; Wouter Schonewille; Robert J. van Oostenbrugge; Diederik W. J. Dippel; Wim H. van Zwam

doi:10.1186/s12883-016-0592-5

The effect of age on outcome after intraarterial treatment in acute ischemic stroke: a MR CLEAN pretrial study

Debbie Beumer^*, Anouk D. Rozeman, Geert J. Lycklama a Nijeholt, Patrick A. Brouwer, Sjoerd F. M. Jenniskens, Ale Algra, Jelis Boiten, Wouter Schonewille, Robert J. van Oostenbrugge, Diederik W. J. Dippel, Wim H. van Zwam

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Background: In recent randomized controlled trials (RCTs) intra-arterial treatment (IAT) has been proven effective and safe for patients with acute ischemic stroke (AIS). So far, there seemed to be no interaction between older age (>80) and main treatment effect. We studied the association of older age with outcome and adverse events after IAT in a cohort of intra arterially treated patients. Methods and findings: Data from all AIS patients with proven proximal anterior circulation cerebral artery occlusion who were intra arterially treated between 2002 until the start of the MR CLEAN trial were studied retrospectively. Duration of the procedure, recanalization (Thrombolysis In Cerebral Infarction score (TICI)), early neurological recovery (i.e. decrease on NIHSS of >= 8 points) after one week or at discharge, good functional outcome at discharge by modified Rankin Scale (mRS

Original language	English
Article number	68
Journal	BMC Neurology
Volume	16
Issue number	1
DOIs	https://doi.org/10.1186/s12883-016-0592-5
Publication status	Published - 17 May 2016

Keywords

Intra-arterial treatment
Older age
Acute ischemic stroke

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Beumer, D., Rozeman, A. D., Nijeholt, G. J. L. A., Brouwer, P. A., Jenniskens, S. F. M., Algra, A., Boiten, J., Schonewille, W., van Oostenbrugge, R. J., Dippel, D. W. J., & van Zwam, W. H. (2016). The effect of age on outcome after intraarterial treatment in acute ischemic stroke: a MR CLEAN pretrial study. BMC Neurology, 16(1), Article 68. https://doi.org/10.1186/s12883-016-0592-5

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title = "The effect of age on outcome after intraarterial treatment in acute ischemic stroke: a MR CLEAN pretrial study",

abstract = "Background: In recent randomized controlled trials (RCTs) intra-arterial treatment (IAT) has been proven effective and safe for patients with acute ischemic stroke (AIS). So far, there seemed to be no interaction between older age (>80) and main treatment effect. We studied the association of older age with outcome and adverse events after IAT in a cohort of intra arterially treated patients. Methods and findings: Data from all AIS patients with proven proximal anterior circulation cerebral artery occlusion who were intra arterially treated between 2002 until the start of the MR CLEAN trial were studied retrospectively. Duration of the procedure, recanalization (Thrombolysis In Cerebral Infarction score (TICI)), early neurological recovery (i.e. decrease on NIHSS of >= 8 points) after one week or at discharge, good functional outcome at discharge by modified Rankin Scale (mRS ",

keywords = "Intra-arterial treatment, Older age, Acute ischemic stroke",

author = "Debbie Beumer and Rozeman, {Anouk D.} and Nijeholt, {Geert J. Lycklama a} and Brouwer, {Patrick A.} and Jenniskens, {Sjoerd F. M.} and Ale Algra and Jelis Boiten and Wouter Schonewille and {van Oostenbrugge}, {Robert J.} and Dippel, {Diederik W. J.} and {van Zwam}, {Wim H.}",

year = "2016",

month = may,

day = "17",

doi = "10.1186/s12883-016-0592-5",

language = "English",

volume = "16",

journal = "BMC Neurology",

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T1 - The effect of age on outcome after intraarterial treatment in acute ischemic stroke: a MR CLEAN pretrial study

AU - Beumer, Debbie

AU - Rozeman, Anouk D.

AU - Nijeholt, Geert J. Lycklama a

AU - Brouwer, Patrick A.

AU - Jenniskens, Sjoerd F. M.

AU - Algra, Ale

AU - Boiten, Jelis

AU - Schonewille, Wouter

AU - van Oostenbrugge, Robert J.

AU - Dippel, Diederik W. J.

AU - van Zwam, Wim H.

PY - 2016/5/17

Y1 - 2016/5/17

N2 - Background: In recent randomized controlled trials (RCTs) intra-arterial treatment (IAT) has been proven effective and safe for patients with acute ischemic stroke (AIS). So far, there seemed to be no interaction between older age (>80) and main treatment effect. We studied the association of older age with outcome and adverse events after IAT in a cohort of intra arterially treated patients. Methods and findings: Data from all AIS patients with proven proximal anterior circulation cerebral artery occlusion who were intra arterially treated between 2002 until the start of the MR CLEAN trial were studied retrospectively. Duration of the procedure, recanalization (Thrombolysis In Cerebral Infarction score (TICI)), early neurological recovery (i.e. decrease on NIHSS of >= 8 points) after one week or at discharge, good functional outcome at discharge by modified Rankin Scale (mRS

AB - Background: In recent randomized controlled trials (RCTs) intra-arterial treatment (IAT) has been proven effective and safe for patients with acute ischemic stroke (AIS). So far, there seemed to be no interaction between older age (>80) and main treatment effect. We studied the association of older age with outcome and adverse events after IAT in a cohort of intra arterially treated patients. Methods and findings: Data from all AIS patients with proven proximal anterior circulation cerebral artery occlusion who were intra arterially treated between 2002 until the start of the MR CLEAN trial were studied retrospectively. Duration of the procedure, recanalization (Thrombolysis In Cerebral Infarction score (TICI)), early neurological recovery (i.e. decrease on NIHSS of >= 8 points) after one week or at discharge, good functional outcome at discharge by modified Rankin Scale (mRS

KW - Intra-arterial treatment

KW - Older age

KW - Acute ischemic stroke

U2 - 10.1186/s12883-016-0592-5

DO - 10.1186/s12883-016-0592-5

M3 - Article

C2 - 27185043

SN - 1471-2377

VL - 16

JO - BMC Neurology

JF - BMC Neurology

IS - 1

M1 - 68

ER -

The effect of age on outcome after intraarterial treatment in acute ischemic stroke: a MR CLEAN pretrial study

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