The Dutch Incidence of Infantile Hypertrophic Pyloric Stenosis and the Influence of Seasons

Fenne A. I. M. van den Bunder*, Jan Hein Allema, Marc A. Benninga, Ivo de Blaauw, Tim van de Brug, Marcel den Dulk, Jan B. F. Hulscher, Claudia M. G. Keyzer-Dekker, Marieke J. Witvliet, Ernest L. W. van Heurn, Joep P. M. Derikx

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Introduction Studies report contradicting results on the incidence of infantile hypertrophic pyloric stenosis (IHPS) and its association with seasons. We aim to assess the IHPS incidence in the Netherlands and to determine whether seasonal variation is present in a nationwide cohort.

Materials and Methods All infants with IHPS hospitalized in the Netherlands between 2007 and 2017 were included in this retrospective cohort study. Incidence rates per 1,000 livebirths (LB) were calculated using total number of LB during the matched month, season, or year, respectively. Seasonal variation based on month of birth and month of surgery was analyzed using linear mixed model and one-way ANOVA, respectively.

Results A total of 2,479 infants were included, of which the majority was male (75.9%). Median (interquartile range) age at surgery was 34 (18) days. The average IHPS incidence rate was 1.28 per 1,000 LB (variation: 1.09-1.47 per 1,000 LB). We did not find a conclusive trend over time in IHPS incidence. Differences in incidence between season of birth and season of surgery were not significant ( p =0.677 and p =0.206, respectively).

Conclusion We found an average IHPS incidence of 1.28 per 1,000 LB in the Netherlands. Our results showed no changing trend in incidence and no seasonal variation.

Original languageEnglish
Pages (from-to)525-529
Number of pages5
JournalEuropean Journal of Pediatric Surgery
Issue number06
Early online date10 Nov 2020
Publication statusPublished - Dec 2021


  • hypertrophic pyloric stenosis
  • infantile hypertrophic pyloric stenosis
  • incidence
  • seasonal variation
  • epidemiology
  • RISK


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