The Dutch Incidence of Infantile Hypertrophic Pyloric Stenosis and the Influence of Seasons

Fenne A. I. M. van den Bunder; Jan Hein Allema; Marc A. Benninga; Ivo de Blaauw; Tim van de Brug; Marcel den Dulk; Jan B. F. Hulscher; Claudia M. G. Keyzer-Dekker; Marieke J. Witvliet; Ernest L. W. van Heurn; Joep P. M. Derikx

doi:10.1055/s-0040-1721055

The Dutch Incidence of Infantile Hypertrophic Pyloric Stenosis and the Influence of Seasons

Fenne A. I. M. van den Bunder^*, Jan Hein Allema, Marc A. Benninga, Ivo de Blaauw, Tim van de Brug, Marcel den Dulk, Jan B. F. Hulscher, Claudia M. G. Keyzer-Dekker, Marieke J. Witvliet, Ernest L. W. van Heurn, Joep P. M. Derikx

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Introduction Studies report contradicting results on the incidence of infantile hypertrophic pyloric stenosis (IHPS) and its association with seasons. We aim to assess the IHPS incidence in the Netherlands and to determine whether seasonal variation is present in a nationwide cohort.

Materials and Methods All infants with IHPS hospitalized in the Netherlands between 2007 and 2017 were included in this retrospective cohort study. Incidence rates per 1,000 livebirths (LB) were calculated using total number of LB during the matched month, season, or year, respectively. Seasonal variation based on month of birth and month of surgery was analyzed using linear mixed model and one-way ANOVA, respectively.

Results A total of 2,479 infants were included, of which the majority was male (75.9%). Median (interquartile range) age at surgery was 34 (18) days. The average IHPS incidence rate was 1.28 per 1,000 LB (variation: 1.09-1.47 per 1,000 LB). We did not find a conclusive trend over time in IHPS incidence. Differences in incidence between season of birth and season of surgery were not significant ( p =0.677 and p =0.206, respectively).

Conclusion We found an average IHPS incidence of 1.28 per 1,000 LB in the Netherlands. Our results showed no changing trend in incidence and no seasonal variation.

Original language	English
Pages (from-to)	525-529
Number of pages	5
Journal	European Journal of Pediatric Surgery
Volume	31
Issue number	06
Early online date	10 Nov 2020
DOIs	https://doi.org/10.1055/s-0040-1721055
Publication status	Published - Dec 2021

Keywords

hypertrophic pyloric stenosis
infantile hypertrophic pyloric stenosis
incidence
seasonal variation
epidemiology
EPIDEMIOLOGY
ASSOCIATION
RISK

Access to Document

10.1055/s-0040-1721055

Cite this

van den Bunder, F. A. I. M., Allema, J. H., Benninga, M. A., de Blaauw, I., van de Brug, T., den Dulk, M., Hulscher, J. B. F., Keyzer-Dekker, C. M. G., Witvliet, M. J., van Heurn, E. L. W., & Derikx, J. P. M. (2021). The Dutch Incidence of Infantile Hypertrophic Pyloric Stenosis and the Influence of Seasons. European Journal of Pediatric Surgery, 31(06), 525-529. https://doi.org/10.1055/s-0040-1721055

@article{3858445306304a9ea84ed9a7339a91db,

title = "The Dutch Incidence of Infantile Hypertrophic Pyloric Stenosis and the Influence of Seasons",

abstract = "Introduction Studies report contradicting results on the incidence of infantile hypertrophic pyloric stenosis (IHPS) and its association with seasons. We aim to assess the IHPS incidence in the Netherlands and to determine whether seasonal variation is present in a nationwide cohort.Materials and Methods All infants with IHPS hospitalized in the Netherlands between 2007 and 2017 were included in this retrospective cohort study. Incidence rates per 1,000 livebirths (LB) were calculated using total number of LB during the matched month, season, or year, respectively. Seasonal variation based on month of birth and month of surgery was analyzed using linear mixed model and one-way ANOVA, respectively.Results A total of 2,479 infants were included, of which the majority was male (75.9%). Median (interquartile range) age at surgery was 34 (18) days. The average IHPS incidence rate was 1.28 per 1,000 LB (variation: 1.09-1.47 per 1,000 LB). We did not find a conclusive trend over time in IHPS incidence. Differences in incidence between season of birth and season of surgery were not significant ( p =0.677 and p =0.206, respectively).Conclusion We found an average IHPS incidence of 1.28 per 1,000 LB in the Netherlands. Our results showed no changing trend in incidence and no seasonal variation.",

keywords = "hypertrophic pyloric stenosis, infantile hypertrophic pyloric stenosis, incidence, seasonal variation, epidemiology, EPIDEMIOLOGY, ASSOCIATION, RISK",

author = "{van den Bunder}, {Fenne A. I. M.} and Allema, {Jan Hein} and Benninga, {Marc A.} and {de Blaauw}, Ivo and {van de Brug}, Tim and {den Dulk}, Marcel and Hulscher, {Jan B. F.} and Keyzer-Dekker, {Claudia M. G.} and Witvliet, {Marieke J.} and {van Heurn}, {Ernest L. W.} and Derikx, {Joep P. M.}",

year = "2021",

month = dec,

doi = "10.1055/s-0040-1721055",

language = "English",

volume = "31",

pages = "525--529",

journal = "European Journal of Pediatric Surgery",

issn = "0939-7248",

publisher = "Thieme Medical Publishers",

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van den Bunder, FAIM, Allema, JH, Benninga, MA, de Blaauw, I, van de Brug, T, den Dulk, M, Hulscher, JBF, Keyzer-Dekker, CMG, Witvliet, MJ, van Heurn, ELW & Derikx, JPM 2021, 'The Dutch Incidence of Infantile Hypertrophic Pyloric Stenosis and the Influence of Seasons', European Journal of Pediatric Surgery, vol. 31, no. 06, pp. 525-529. https://doi.org/10.1055/s-0040-1721055

TY - JOUR

T1 - The Dutch Incidence of Infantile Hypertrophic Pyloric Stenosis and the Influence of Seasons

AU - van den Bunder, Fenne A. I. M.

AU - Allema, Jan Hein

AU - Benninga, Marc A.

AU - de Blaauw, Ivo

AU - van de Brug, Tim

AU - den Dulk, Marcel

AU - Hulscher, Jan B. F.

AU - Keyzer-Dekker, Claudia M. G.

AU - Witvliet, Marieke J.

AU - van Heurn, Ernest L. W.

AU - Derikx, Joep P. M.

PY - 2021/12

Y1 - 2021/12

N2 - Introduction Studies report contradicting results on the incidence of infantile hypertrophic pyloric stenosis (IHPS) and its association with seasons. We aim to assess the IHPS incidence in the Netherlands and to determine whether seasonal variation is present in a nationwide cohort.Materials and Methods All infants with IHPS hospitalized in the Netherlands between 2007 and 2017 were included in this retrospective cohort study. Incidence rates per 1,000 livebirths (LB) were calculated using total number of LB during the matched month, season, or year, respectively. Seasonal variation based on month of birth and month of surgery was analyzed using linear mixed model and one-way ANOVA, respectively.Results A total of 2,479 infants were included, of which the majority was male (75.9%). Median (interquartile range) age at surgery was 34 (18) days. The average IHPS incidence rate was 1.28 per 1,000 LB (variation: 1.09-1.47 per 1,000 LB). We did not find a conclusive trend over time in IHPS incidence. Differences in incidence between season of birth and season of surgery were not significant ( p =0.677 and p =0.206, respectively).Conclusion We found an average IHPS incidence of 1.28 per 1,000 LB in the Netherlands. Our results showed no changing trend in incidence and no seasonal variation.

AB - Introduction Studies report contradicting results on the incidence of infantile hypertrophic pyloric stenosis (IHPS) and its association with seasons. We aim to assess the IHPS incidence in the Netherlands and to determine whether seasonal variation is present in a nationwide cohort.Materials and Methods All infants with IHPS hospitalized in the Netherlands between 2007 and 2017 were included in this retrospective cohort study. Incidence rates per 1,000 livebirths (LB) were calculated using total number of LB during the matched month, season, or year, respectively. Seasonal variation based on month of birth and month of surgery was analyzed using linear mixed model and one-way ANOVA, respectively.Results A total of 2,479 infants were included, of which the majority was male (75.9%). Median (interquartile range) age at surgery was 34 (18) days. The average IHPS incidence rate was 1.28 per 1,000 LB (variation: 1.09-1.47 per 1,000 LB). We did not find a conclusive trend over time in IHPS incidence. Differences in incidence between season of birth and season of surgery were not significant ( p =0.677 and p =0.206, respectively).Conclusion We found an average IHPS incidence of 1.28 per 1,000 LB in the Netherlands. Our results showed no changing trend in incidence and no seasonal variation.

KW - hypertrophic pyloric stenosis

KW - infantile hypertrophic pyloric stenosis

KW - incidence

KW - seasonal variation

KW - epidemiology

KW - EPIDEMIOLOGY

KW - ASSOCIATION

KW - RISK

U2 - 10.1055/s-0040-1721055

DO - 10.1055/s-0040-1721055

M3 - Article

C2 - 33171518

SN - 0939-7248

VL - 31

SP - 525

EP - 529

JO - European Journal of Pediatric Surgery

JF - European Journal of Pediatric Surgery

IS - 06

ER -