The convergence of high-tech emerging technologies into the next stage of organ-on-a-chips

Alessandro Polini; Lorenzo Moroni

doi:10.1016/j.bbiosy.2021.100012

The convergence of high-tech emerging technologies into the next stage of organ-on-a-chips

Alessandro Polini^*, Lorenzo Moroni^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Recently, organ-on-a-chips (OoCs) have been proposed as highly innovative, truly predictive tools with limitless potential for organ function modelling, drug discovery and testing. By mimicking human key organ functions in vitro, they are proposed as models for studying physiological processes as well as disease-related mechanisms to elucidate pathological pathways and test the safety and efficacy of potential drug candidates, with unprecedented degree of physiological and clinical relevance. Despite the numerous efforts from biology and engineering, we expect that OoC will reach the next level by benefitting from high-tech technologies such as biofabrication, artificial intelligence (AI), robotics and automation.

Original language	English
Article number	100012
Journal	Biomaterials and Biosystems
Volume	1
DOIs	https://doi.org/10.1016/j.bbiosy.2021.100012
Publication status	Published - 1 Mar 2021

Keywords

Artificial intelligence
Automation
Biofabrication
Bioprinting
Microfluidics
Microphysiological systems
Organ modelling
Organ-on-a-chips
Robotics

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10.1016/j.bbiosy.2021.100012Licence: CC BY-NC-ND

Cite this

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title = "The convergence of high-tech emerging technologies into the next stage of organ-on-a-chips",

abstract = "Recently, organ-on-a-chips (OoCs) have been proposed as highly innovative, truly predictive tools with limitless potential for organ function modelling, drug discovery and testing. By mimicking human key organ functions in vitro, they are proposed as models for studying physiological processes as well as disease-related mechanisms to elucidate pathological pathways and test the safety and efficacy of potential drug candidates, with unprecedented degree of physiological and clinical relevance. Despite the numerous efforts from biology and engineering, we expect that OoC will reach the next level by benefitting from high-tech technologies such as biofabrication, artificial intelligence (AI), robotics and automation.",

keywords = "Artificial intelligence, Automation, Biofabrication, Bioprinting, Microfluidics, Microphysiological systems, Organ modelling, Organ-on-a-chips, Robotics",

author = "Alessandro Polini and Lorenzo Moroni",

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AU - Moroni, Lorenzo

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N2 - Recently, organ-on-a-chips (OoCs) have been proposed as highly innovative, truly predictive tools with limitless potential for organ function modelling, drug discovery and testing. By mimicking human key organ functions in vitro, they are proposed as models for studying physiological processes as well as disease-related mechanisms to elucidate pathological pathways and test the safety and efficacy of potential drug candidates, with unprecedented degree of physiological and clinical relevance. Despite the numerous efforts from biology and engineering, we expect that OoC will reach the next level by benefitting from high-tech technologies such as biofabrication, artificial intelligence (AI), robotics and automation.

AB - Recently, organ-on-a-chips (OoCs) have been proposed as highly innovative, truly predictive tools with limitless potential for organ function modelling, drug discovery and testing. By mimicking human key organ functions in vitro, they are proposed as models for studying physiological processes as well as disease-related mechanisms to elucidate pathological pathways and test the safety and efficacy of potential drug candidates, with unprecedented degree of physiological and clinical relevance. Despite the numerous efforts from biology and engineering, we expect that OoC will reach the next level by benefitting from high-tech technologies such as biofabrication, artificial intelligence (AI), robotics and automation.

KW - Artificial intelligence

KW - Automation

KW - Biofabrication

KW - Bioprinting

KW - Microfluidics

KW - Microphysiological systems

KW - Organ modelling

KW - Organ-on-a-chips

KW - Robotics

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DO - 10.1016/j.bbiosy.2021.100012

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