Abstract
Vitamin K-dependent (VKD) proteins, including the mineralization inhibitor matrix-gla protein (MGP), are found in joint tissues including cartilage and bone. Previous studies suggest low vitamin K status is associated with higher osteoarthritis (OA) prevalence and incidence.To clarify what joint tissues vitamin K is relevant to in OA, we investigated the cross-sectional and longitudinal association between vitamin K status and knee OA structural features measured using magnetic resonance imaging (MRI).Plasma phylloquinone (PK, vitamin K1) and dephosphorylated-uncarboxylated MGP ((dp)ucMGP) were measured in 791 older community-dwelling adults who had bilateral knee MRIs (mean ? SD age = 74 ? 3 y; 67% female). The adjusted odds ratios (and 95% confidence intervals) [OR (95%CI)] for presence and progression of knee OA features according to vitamin K status were calculated using marginal models with generalized estimating equations (GEEs), adjusted for age, sex, body mass index (BMI), triglycerides and other pertinent confounders.Longitudinally, participants with very low plasma PK (
Original language | English |
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Pages (from-to) | 370-378 |
Journal | Osteoarthritis and Cartilage |
Volume | 23 |
Issue number | 3 |
DOIs | |
Publication status | Published - Mar 2015 |
Keywords
- Osteoarthritis
- Nutrition
- Phylloquinone
- Vitamin K
- Matrix gla protein
- Epidemiology