The association between vitamin K status and knee osteoarthritis features in older adults: The Health, Aging and Body Composition Study

M. K. Shea*, S. B. Kritchevsky, F. -C. Hsu, M. Nevitt, S. L. Booth, C. K. Kwoh, T. E. McAlindon, C. Vermeer, N. Drummen, T. B. Harris, C. Womack, R. F. Loeser

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Vitamin K-dependent (VKD) proteins, including the mineralization inhibitor matrix-gla protein (MGP), are found in joint tissues including cartilage and bone. Previous studies suggest low vitamin K status is associated with higher osteoarthritis (OA) prevalence and incidence.To clarify what joint tissues vitamin K is relevant to in OA, we investigated the cross-sectional and longitudinal association between vitamin K status and knee OA structural features measured using magnetic resonance imaging (MRI).Plasma phylloquinone (PK, vitamin K1) and dephosphorylated-uncarboxylated MGP ((dp)ucMGP) were measured in 791 older community-dwelling adults who had bilateral knee MRIs (mean ? SD age = 74 ? 3 y; 67% female). The adjusted odds ratios (and 95% confidence intervals) [OR (95%CI)] for presence and progression of knee OA features according to vitamin K status were calculated using marginal models with generalized estimating equations (GEEs), adjusted for age, sex, body mass index (BMI), triglycerides and other pertinent confounders.Longitudinally, participants with very low plasma PK (
Original languageEnglish
Pages (from-to)370-378
JournalOsteoarthritis and Cartilage
Issue number3
Publication statusPublished - Mar 2015


  • Osteoarthritis
  • Nutrition
  • Phylloquinone
  • Vitamin K
  • Matrix gla protein
  • Epidemiology

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