TY - JOUR
T1 - The association between polygenic risk scores for mental disorders and social cognition
T2 - A scoping review
AU - Fusar-Poli, Laura
AU - Rodolico, Alessandro
AU - Martinez, Miriam
AU - Fichera, Clarissa
AU - Lin, Bochao D.
AU - Basadonne, Ilaria
AU - Concerto, Carmen
AU - Aguglia, Eugenio
AU - Guloksuz, Sinan
AU - Signorelli, Maria Salvina
N1 - Funding Information:
MSS was supported by a Starting Grant (Project: TDPsy) from the University of Catania in the context of the PIano di inCEntivi per la RIcerca di Ateneo 2020/2022 (PIACERI). LF-P was co-funded by the European Union FSE-REACT-EU, PON Research and Innovation 2014–2020 DM 1062/2021 [08-I-17631-1].
Funding Information:
MSS was supported by a Starting Grant (Project: TDPsy) from the University of Catania in the context of the PIano di inCEntivi per la RIcerca di Ateneo 2020/2022 (PIACERI). LF-P was co-funded by the European Union FSE-REACT-EU, PON Research and Innovation 2014–2020 DM 1062/2021 [08-I-17631-1].
Publisher Copyright:
© 2023 Elsevier Ltd
PY - 2023/8/1
Y1 - 2023/8/1
N2 - People with mental disorders, such as psychosis or autism spectrum disorder (ASD), often present impairments in social cognition (SC), which may cause significant difficulties in real-world functioning. SC deficits are seen also in unaffected relatives, indicating a genetic substratum. The present review evaluated the evidence on the association between SC and the polygenic risk score (PRS), a single metric of the molecular genetic risk to develop a specific disorder. In July 2022, we conducted systematic searches in Scopus and PubMed following the PRISMA-ScR guidelines. We selected original articles written in English reporting results on the association between PRSs for any mental disorder and domains of SC either in people with mental disorders or controls. The search yielded 244 papers, of which 13 were selected for inclusion. Studies tested mainly PRSs for schizophrenia, ASD, and attention-deficit hyperactivity disorder. Emotion recognition was the most investigated domain of SC. Overall, evidence revealed that currently available PRSs for mental disorders do not explain variation in SC performances. To enhance the understanding of mechanisms underlying SC in mental disorders, future research should focus on the development of transdiagnostic PRSs, study their interaction with environmental risk factors, and standardize outcome measurement.
AB - People with mental disorders, such as psychosis or autism spectrum disorder (ASD), often present impairments in social cognition (SC), which may cause significant difficulties in real-world functioning. SC deficits are seen also in unaffected relatives, indicating a genetic substratum. The present review evaluated the evidence on the association between SC and the polygenic risk score (PRS), a single metric of the molecular genetic risk to develop a specific disorder. In July 2022, we conducted systematic searches in Scopus and PubMed following the PRISMA-ScR guidelines. We selected original articles written in English reporting results on the association between PRSs for any mental disorder and domains of SC either in people with mental disorders or controls. The search yielded 244 papers, of which 13 were selected for inclusion. Studies tested mainly PRSs for schizophrenia, ASD, and attention-deficit hyperactivity disorder. Emotion recognition was the most investigated domain of SC. Overall, evidence revealed that currently available PRSs for mental disorders do not explain variation in SC performances. To enhance the understanding of mechanisms underlying SC in mental disorders, future research should focus on the development of transdiagnostic PRSs, study their interaction with environmental risk factors, and standardize outcome measurement.
KW - Autistic disorder
KW - Emotions
KW - Environment
KW - Genetics
KW - Psychotic disorders
KW - Theory of mind
UR - http://www.scopus.com/inward/record.url?scp=85164319679&partnerID=8YFLogxK
U2 - 10.1016/j.jpsychires.2023.06.029
DO - 10.1016/j.jpsychires.2023.06.029
M3 - (Systematic) Review article
C2 - 37418886
SN - 0022-3956
VL - 164
SP - 389
EP - 401
JO - Journal of Psychiatric Research
JF - Journal of Psychiatric Research
IS - 1
ER -