The Assisi Think Tank Meeting Survey of post-mastectomy radiation therapy in ductal carcinoma in situ: Suggestions for routine practice

A. Montero-Luis; C. Aristei; I. Meattini; M. Arenas; L. Boersma; C. Bourgier; C. Coles; B. Cutuli; L. Falcinelli; O. Kaidar-Person; M. C. Leonardi; B. Offersen; F. Marazzi; S. Rivera; L. Tagliaferri; V. Tombolini; C. Vidali; V. Valentini; P. Poortmans

doi:10.1016/j.critrevonc.2019.04.016

The Assisi Think Tank Meeting Survey of post-mastectomy radiation therapy in ductal carcinoma in situ: Suggestions for routine practice

A. Montero-Luis^*, C. Aristei, I. Meattini, M. Arenas, L. Boersma, C. Bourgier, C. Coles, B. Cutuli, L. Falcinelli, O. Kaidar-Person, M. C. Leonardi, B. Offersen, F. Marazzi, S. Rivera, L. Tagliaferri, V. Tombolini, C. Vidali, V. Valentini, P. Poortmans

^*Corresponding author for this work

Research output: Contribution to journal › (Systematic) Review article › peer-review

Abstract

Background: Risk factors for local recurrence after mastectomy in ductal carcinoma in situ (DCIS) emerged as a grey area during the second "Assisi Think Tank Meeting" (ATTM) on Breast Cancer.

Aim: To review practice patterns of post-mastectomy radiation therapy (PMRT) in DCIS, identify risk factors for recurrence and select suitable candidates for PMRT.

Methods: A questionnaire concerning DCIS management, focusing on PMRT, was distributed online via SurveyMonkey.

Results: 142 responses were received from 15 countries. The majority worked in academic institutions, had 5-20 years work-experience and irradiated <5 DCIS patients/year. PMRT was more given if: surgical margins <1 mm, high-grade, multicentricity, young age, tumour size > 5 cm, skin- or nipple- sparing mastectomy. Moderate hypofractionation was the most common schedule, except after immediate breast reconstruction (57% conventional fractionation).

Conclusions: The present survey highlighted risk factors for PMRT administration, which should be further evaluated.

Original language	English
Pages (from-to)	207-213
Number of pages	7
Journal	Critical Reviews in Oncology/Hematology
Volume	138
DOIs	https://doi.org/10.1016/j.critrevonc.2019.04.016
Publication status	Published - Jun 2019

Keywords

Breast cancer
Ductal carcinoma in situ
Post-mastectomy radiotherapy
Hypofractionation
Survey
BREAST-CONSERVING SURGERY
RADIOTHERAPY NSABP B-35
LONG-TERM OUTCOMES
LOCAL RECURRENCE
DOUBLE-BLIND
POSTMENOPAUSAL WOMEN
UK STANDARDIZATION
CANCER
MASTECTOMY
TAMOXIFEN

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10.1016/j.critrevonc.2019.04.016

Cite this

Montero-Luis, A., Aristei, C., Meattini, I., Arenas, M., Boersma, L., Bourgier, C., Coles, C., Cutuli, B., Falcinelli, L., Kaidar-Person, O., Leonardi, M. C., Offersen, B., Marazzi, F., Rivera, S., Tagliaferri, L., Tombolini, V., Vidali, C., Valentini, V., & Poortmans, P. (2019). The Assisi Think Tank Meeting Survey of post-mastectomy radiation therapy in ductal carcinoma in situ: Suggestions for routine practice. Critical Reviews in Oncology/Hematology, 138, 207-213. https://doi.org/10.1016/j.critrevonc.2019.04.016

@article{228cf32cf6bf4c8d8453957f93928adc,

title = "The Assisi Think Tank Meeting Survey of post-mastectomy radiation therapy in ductal carcinoma in situ: Suggestions for routine practice",

abstract = "Background: Risk factors for local recurrence after mastectomy in ductal carcinoma in situ (DCIS) emerged as a grey area during the second {"}Assisi Think Tank Meeting{"} (ATTM) on Breast Cancer.Aim: To review practice patterns of post-mastectomy radiation therapy (PMRT) in DCIS, identify risk factors for recurrence and select suitable candidates for PMRT.Methods: A questionnaire concerning DCIS management, focusing on PMRT, was distributed online via SurveyMonkey.Results: 142 responses were received from 15 countries. The majority worked in academic institutions, had 5-20 years work-experience and irradiated <5 DCIS patients/year. PMRT was more given if: surgical margins <1 mm, high-grade, multicentricity, young age, tumour size > 5 cm, skin- or nipple- sparing mastectomy. Moderate hypofractionation was the most common schedule, except after immediate breast reconstruction (57% conventional fractionation).Conclusions: The present survey highlighted risk factors for PMRT administration, which should be further evaluated.",

keywords = "Breast cancer, Ductal carcinoma in situ, Post-mastectomy radiotherapy, Hypofractionation, Survey, BREAST-CONSERVING SURGERY, RADIOTHERAPY NSABP B-35, LONG-TERM OUTCOMES, LOCAL RECURRENCE, DOUBLE-BLIND, POSTMENOPAUSAL WOMEN, UK STANDARDIZATION, CANCER, MASTECTOMY, TAMOXIFEN",

author = "A. Montero-Luis and C. Aristei and I. Meattini and M. Arenas and L. Boersma and C. Bourgier and C. Coles and B. Cutuli and L. Falcinelli and O. Kaidar-Person and Leonardi, {M. C.} and B. Offersen and F. Marazzi and S. Rivera and L. Tagliaferri and V. Tombolini and C. Vidali and V. Valentini and P. Poortmans",

note = "Publisher Copyright: {\textcopyright} 2019 Elsevier B.V.",

year = "2019",

month = jun,

doi = "10.1016/j.critrevonc.2019.04.016",

language = "English",

volume = "138",

pages = "207--213",

journal = "Critical Reviews in Oncology/Hematology",

issn = "1040-8428",

publisher = "Elsevier Science",

}

Montero-Luis, A, Aristei, C, Meattini, I, Arenas, M, Boersma, L, Bourgier, C, Coles, C, Cutuli, B, Falcinelli, L, Kaidar-Person, O, Leonardi, MC, Offersen, B, Marazzi, F, Rivera, S, Tagliaferri, L, Tombolini, V, Vidali, C, Valentini, V & Poortmans, P 2019, 'The Assisi Think Tank Meeting Survey of post-mastectomy radiation therapy in ductal carcinoma in situ: Suggestions for routine practice', Critical Reviews in Oncology/Hematology, vol. 138, pp. 207-213. https://doi.org/10.1016/j.critrevonc.2019.04.016

TY - JOUR

T1 - The Assisi Think Tank Meeting Survey of post-mastectomy radiation therapy in ductal carcinoma in situ

T2 - Suggestions for routine practice

AU - Montero-Luis, A.

AU - Aristei, C.

AU - Meattini, I.

AU - Arenas, M.

AU - Boersma, L.

AU - Bourgier, C.

AU - Coles, C.

AU - Cutuli, B.

AU - Falcinelli, L.

AU - Kaidar-Person, O.

AU - Leonardi, M. C.

AU - Offersen, B.

AU - Marazzi, F.

AU - Rivera, S.

AU - Tagliaferri, L.

AU - Tombolini, V.

AU - Vidali, C.

AU - Valentini, V.

AU - Poortmans, P.

PY - 2019/6

Y1 - 2019/6

N2 - Background: Risk factors for local recurrence after mastectomy in ductal carcinoma in situ (DCIS) emerged as a grey area during the second "Assisi Think Tank Meeting" (ATTM) on Breast Cancer.Aim: To review practice patterns of post-mastectomy radiation therapy (PMRT) in DCIS, identify risk factors for recurrence and select suitable candidates for PMRT.Methods: A questionnaire concerning DCIS management, focusing on PMRT, was distributed online via SurveyMonkey.Results: 142 responses were received from 15 countries. The majority worked in academic institutions, had 5-20 years work-experience and irradiated <5 DCIS patients/year. PMRT was more given if: surgical margins <1 mm, high-grade, multicentricity, young age, tumour size > 5 cm, skin- or nipple- sparing mastectomy. Moderate hypofractionation was the most common schedule, except after immediate breast reconstruction (57% conventional fractionation).Conclusions: The present survey highlighted risk factors for PMRT administration, which should be further evaluated.

AB - Background: Risk factors for local recurrence after mastectomy in ductal carcinoma in situ (DCIS) emerged as a grey area during the second "Assisi Think Tank Meeting" (ATTM) on Breast Cancer.Aim: To review practice patterns of post-mastectomy radiation therapy (PMRT) in DCIS, identify risk factors for recurrence and select suitable candidates for PMRT.Methods: A questionnaire concerning DCIS management, focusing on PMRT, was distributed online via SurveyMonkey.Results: 142 responses were received from 15 countries. The majority worked in academic institutions, had 5-20 years work-experience and irradiated <5 DCIS patients/year. PMRT was more given if: surgical margins <1 mm, high-grade, multicentricity, young age, tumour size > 5 cm, skin- or nipple- sparing mastectomy. Moderate hypofractionation was the most common schedule, except after immediate breast reconstruction (57% conventional fractionation).Conclusions: The present survey highlighted risk factors for PMRT administration, which should be further evaluated.

KW - Breast cancer

KW - Ductal carcinoma in situ

KW - Post-mastectomy radiotherapy

KW - Hypofractionation

KW - Survey

KW - BREAST-CONSERVING SURGERY

KW - RADIOTHERAPY NSABP B-35

KW - LONG-TERM OUTCOMES

KW - LOCAL RECURRENCE

KW - DOUBLE-BLIND

KW - POSTMENOPAUSAL WOMEN

KW - UK STANDARDIZATION

KW - CANCER

KW - MASTECTOMY

KW - TAMOXIFEN

U2 - 10.1016/j.critrevonc.2019.04.016

DO - 10.1016/j.critrevonc.2019.04.016

M3 - (Systematic) Review article

C2 - 31092377

SN - 1040-8428

VL - 138

SP - 207

EP - 213

JO - Critical Reviews in Oncology/Hematology

JF - Critical Reviews in Oncology/Hematology

ER -