The anti-malarial drug chloroquine sensitizes oncogenic NOTCH1 driven human T-ALL to gamma-secretase inhibition

Judith Hounjet; Roger Habets; Marco B. Schaaf; Tessa C. Hendrickx; Lydie M. O. Barbeau; Sanaz Yahyanejad; Kasper M. Rouschop; Arjan J. Groot; Marc Vooijs

doi:10.1038/s41388-019-0802-x

The anti-malarial drug chloroquine sensitizes oncogenic NOTCH1 driven human T-ALL to gamma-secretase inhibition

Judith Hounjet, Roger Habets, Marco B. Schaaf, Tessa C. Hendrickx, Lydie M. O. Barbeau, Sanaz Yahyanejad, Kasper M. Rouschop, Arjan J. Groot, Marc Vooijs^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Original language	English
Pages (from-to)	5457-5468
Number of pages	12
Journal	Oncogene
Volume	38
Issue number	27
DOIs	https://doi.org/10.1038/s41388-019-0802-x
Publication status	Published - 4 Jul 2019

Keywords

GENE-EXPRESSION
CELL-DEATH
AUTOPHAGY
ACTIVATION
RESISTANCE
MUTATIONS
REGULATOR
PROTEIN
CANCER
CYTOTOXICITY

Access to Document

10.1038/s41388-019-0802-x

Cite this

Hounjet, J., Habets, R., Schaaf, M. B., Hendrickx, T. C., Barbeau, L. M. O., Yahyanejad, S., Rouschop, K. M., Groot, A. J., & Vooijs, M. (2019). The anti-malarial drug chloroquine sensitizes oncogenic NOTCH1 driven human T-ALL to gamma-secretase inhibition. Oncogene, 38(27), 5457-5468. https://doi.org/10.1038/s41388-019-0802-x

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author = "Judith Hounjet and Roger Habets and Schaaf, {Marco B.} and Hendrickx, {Tessa C.} and Barbeau, {Lydie M. O.} and Sanaz Yahyanejad and Rouschop, {Kasper M.} and Groot, {Arjan J.} and Marc Vooijs",

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The anti-malarial drug chloroquine sensitizes oncogenic NOTCH1 driven human T-ALL to gamma-secretase inhibition. / Hounjet, Judith; Habets, Roger; Schaaf, Marco B.; Hendrickx, Tessa C.; Barbeau, Lydie M. O.; Yahyanejad, Sanaz; Rouschop, Kasper M.; Groot, Arjan J.; Vooijs, Marc.

In: Oncogene, Vol. 38, No. 27, 04.07.2019, p. 5457-5468.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - The anti-malarial drug chloroquine sensitizes oncogenic NOTCH1 driven human T-ALL to gamma-secretase inhibition

AU - Hounjet, Judith

AU - Habets, Roger

AU - Schaaf, Marco B.

AU - Hendrickx, Tessa C.

AU - Barbeau, Lydie M. O.

AU - Yahyanejad, Sanaz

AU - Rouschop, Kasper M.

AU - Groot, Arjan J.

AU - Vooijs, Marc

PY - 2019/7/4

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KW - GENE-EXPRESSION

KW - CELL-DEATH

KW - AUTOPHAGY

KW - ACTIVATION

KW - RESISTANCE

KW - MUTATIONS

KW - REGULATOR

KW - PROTEIN

KW - CANCER

KW - CYTOTOXICITY

U2 - 10.1038/s41388-019-0802-x

DO - 10.1038/s41388-019-0802-x

M3 - Article

VL - 38

SP - 5457

EP - 5468

JO - Oncogene

JF - Oncogene

SN - 0950-9232

IS - 27

ER -