The 2022 Assisi Think Tank Meeting: White paper on optimising radiation therapy for breast cancer

C. Aristei*, O. Kaidar-Person, L. Boersma, M. C. Leonardi, B. Offersen, P. Franco, M. Arenas, C. Bourgier, R. Pfeffer, V. Kouloulias, Y. Bölükbasi, I. Meattini, C. Coles, A. Montero Luis, V. Masiello, I. Palumbo, A. G. Morganti, E. Perrucci, V. Tombolini, M. KrengliF. Marazzi, L. Trigo, S. Borghesi, A. Ciabattoni, I. Ratoša, V. Valentini, P. Poortmans

*Corresponding author for this work

Research output: Contribution to journal(Systematic) Review article peer-review

Abstract

The present white paper, referring to the 4th Assisi Think Tank Meeting on breast cancer, reviews state-of-the-art data, on-going studies and research proposals. <70% agreement in an online questionnaire identified the following clinical challenges: 1: Nodal RT in patients who have a) 1–2 positive sentinel nodes without ALND (axillary lymph node dissection); b) cN1 disease transformed into ypN0 by primary systemic therapy and c) 1–3 positive nodes after mastectomy and ALND. 2. The optimal combination of RT and immunotherapy (IT), patient selection, IT-RT timing, and RT optimal dose, fractionation and target volume. Most experts agreed that RT- IT combination does not enhance toxicity. 3: Re-irradiation for local relapse converged on the use of partial breast irradiation after second breast conserving surgery. Hyperthermia aroused support but is not widely available. Further studies are required to finetune best practice, especially given the increasing use of re-irradiation.
Original languageEnglish
Article number104035
Number of pages16
JournalCritical Reviews in Oncology/Hematology
Volume187
Issue number1
DOIs
Publication statusPublished - 1 Jul 2023

Keywords

  • Breast cancer
  • Combined modality treatment
  • Immunotherapy
  • Radiation therapy
  • Re-irradiation in relapsed patients

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