Th17 expansion in MS patients is counterbalanced by an expanded CD39(+) regulatory T cell population during remission but not during relapse

E. Peelen*, J.G.M.C. Damoiseaux, J. Smolders, S. Knippenberg, P.P.C.A. Menheere, J.W. Tervaert, R.M.M. Hupperts, M.M.G.L. Thewissen

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


In this study, percentages of CD39(+) Treg and Th17 cells were compared between relapsing-remitting MS patients and controls and were related to the vitamin D status. The Th17 cell population was expanded in about 40% of the MS patients. In MS patients in remission, but not during relapse, a positive association was found between Th17 cell and CD39(+) Treg percentages (r=0.468, p=0.007). Since CD39(+) Tregs have been shown to have Th17 suppressive capacities, we propose that a dysregulated Th17/CD39(+) Treg balance might contribute to disease exacerbation. A clear role for vitamin D in this regulation could not be established.
Original languageEnglish
Pages (from-to)97-103
JournalJournal of Neuroimmunology
Publication statusPublished - 1 Jan 2011

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