TY - JOUR
T1 - Th17 expansion in MS patients is counterbalanced by an expanded CD39(+) regulatory T cell population during remission but not during relapse
AU - Peelen, E.
AU - Damoiseaux, J.G.M.C.
AU - Smolders, J.
AU - Knippenberg, S.
AU - Menheere, P.P.C.A.
AU - Tervaert, J.W.
AU - Hupperts, R.M.M.
AU - Thewissen, M.M.G.L.
PY - 2011/1/1
Y1 - 2011/1/1
N2 - In this study, percentages of CD39(+) Treg and Th17 cells were compared between relapsing-remitting MS patients and controls and were related to the vitamin D status. The Th17 cell population was expanded in about 40% of the MS patients. In MS patients in remission, but not during relapse, a positive association was found between Th17 cell and CD39(+) Treg percentages (r=0.468, p=0.007). Since CD39(+) Tregs have been shown to have Th17 suppressive capacities, we propose that a dysregulated Th17/CD39(+) Treg balance might contribute to disease exacerbation. A clear role for vitamin D in this regulation could not be established.
AB - In this study, percentages of CD39(+) Treg and Th17 cells were compared between relapsing-remitting MS patients and controls and were related to the vitamin D status. The Th17 cell population was expanded in about 40% of the MS patients. In MS patients in remission, but not during relapse, a positive association was found between Th17 cell and CD39(+) Treg percentages (r=0.468, p=0.007). Since CD39(+) Tregs have been shown to have Th17 suppressive capacities, we propose that a dysregulated Th17/CD39(+) Treg balance might contribute to disease exacerbation. A clear role for vitamin D in this regulation could not be established.
U2 - 10.1016/j.jneuroim.2011.09.013
DO - 10.1016/j.jneuroim.2011.09.013
M3 - Article
SN - 0165-5728
VL - 240-241
SP - 97
EP - 103
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
ER -