Targeting the CRD F-face of Human Galectin-3 and Allosterically Modulating Glycan Binding by Angiostatic PTX008 and a Structurally Optimized Derivative

Michelle C. Miller, Yi Zheng, Dennis Suylen, Hans Ippel, F. Javier Canada, M. Alvaro Berbis, Jesus Jimenez-Barbero, Guihua Tai, Hans-Joachim Gabius, Kevin H. Mayo*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Pages (from-to)713-723
Number of pages11
JournalChemmedchem
Volume16
Issue number4
Early online date1 Dec 2020
DOIs
Publication statusPublished - 17 Feb 2021

Keywords

  • angiogenesis
  • calixarenes
  • drug design
  • galectin
  • metastasis
  • CHEMICAL-SHIFT ASSIGNMENTS
  • TUMOR-GROWTH
  • N-15 BACKBONE
  • ENDOTHELIAL-CELLS
  • RELEVANT LECTINS
  • COLON-CANCER
  • ANGINEX
  • INHIBITORS
  • ANGIOGENESIS
  • PROTEIN

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