Targeting CD40-Induced TRAF6 Signaling in Macrophages Reduces Atherosclerosis

Tom T. P. Seijkens, Claudia M. van Tiel, Pascal J. H. Kusters, Dorothee Atzler, Oliver Soehnlein, Barbara Zarzycka, Suzanne A. B. M. Aarts, Marnix Lameijer, Marion J. Gijbels, Linda Beckers, Myrthe den Toom, Bram Slutter, Johan Kuiper, Johan Duchene, Maria Aslani, Remco T. A. Megens, Cornelis van 't Veer, Gijs Kooij, Roy Schrijver, Marten A. HoeksemaLouis Boon, Francois Fay, Jun Tang, Samantha Baxter, Aldo Jongejan, Perry D. Moerland, Gert Vriend, Boris Bleijlevens, Edward A. Fisher, Raphael Duivenvoorden, Norbert Gerdes, Menno P. J. de Winther, Gerry A. Nicolaes, Willem J. M. Mulder, Christian Weber, Esther Lutgens

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Pages (from-to)527-542
Number of pages16
JournalJournal of the American College of Cardiology
Volume71
Issue number5
DOIs
Publication statusPublished - 6 Feb 2018

Keywords

  • atherosclerosis
  • drug development
  • immunology
  • inflammation
  • nanotechnology
  • CD40-TRAF6 INTERACTIONS
  • IMMUNE-SYSTEM
  • MICE
  • CD40
  • INHIBITION
  • CELLS
  • ACTIVATION
  • PHENOTYPE
  • MECHANISM
  • THERAPY

Cite this

Seijkens, T. T. P., van Tiel, C. M., Kusters, P. J. H., Atzler, D., Soehnlein, O., Zarzycka, B., Aarts, S. A. B. M., Lameijer, M., Gijbels, M. J., Beckers, L., den Toom, M., Slutter, B., Kuiper, J., Duchene, J., Aslani, M., Megens, R. T. A., van 't Veer, C., Kooij, G., Schrijver, R., ... Lutgens, E. (2018). Targeting CD40-Induced TRAF6 Signaling in Macrophages Reduces Atherosclerosis. Journal of the American College of Cardiology, 71(5), 527-542. https://doi.org/10.1016/j.jacc.2017.11.055