Targeting CD40-Induced TRAF6 Signaling in Macrophages Reduces Atherosclerosis

Tom T. P. Seijkens; Claudia M. van Tiel; Pascal J. H. Kusters; Dorothee Atzler; Oliver Soehnlein; Barbara Zarzycka; Suzanne A. B. M. Aarts; Marnix Lameijer; Marion J. Gijbels; Linda Beckers; Myrthe den Toom; Bram Slutter; Johan Kuiper; Johan Duchene; Maria Aslani; Remco T. A. Megens; Cornelis van 't Veer; Gijs Kooij; Roy Schrijver; Marten A. Hoeksema; Louis Boon; Francois Fay; Jun Tang; Samantha Baxter; Aldo Jongejan; Perry D. Moerland; Gert Vriend; Boris Bleijlevens; Edward A. Fisher; Raphael Duivenvoorden; Norbert Gerdes; Menno P. J. de Winther; Gerry A. Nicolaes; Willem J. M. Mulder; Christian Weber; Esther Lutgens

doi:10.1016/j.jacc.2017.11.055

Targeting CD40-Induced TRAF6 Signaling in Macrophages Reduces Atherosclerosis

Tom T. P. Seijkens, Claudia M. van Tiel, Pascal J. H. Kusters, Dorothee Atzler, Oliver Soehnlein, Barbara Zarzycka, Suzanne A. B. M. Aarts, Marnix Lameijer, Marion J. Gijbels, Linda Beckers, Myrthe den Toom, Bram Slutter, Johan Kuiper, Johan Duchene, Maria Aslani, Remco T. A. Megens, Cornelis van 't Veer, Gijs Kooij, Roy Schrijver, Marten A. HoeksemaLouis Boon, Francois Fay, Jun Tang, Samantha Baxter, Aldo Jongejan, Perry D. Moerland, Gert Vriend, Boris Bleijlevens, Edward A. Fisher, Raphael Duivenvoorden, Norbert Gerdes, Menno P. J. de Winther, Gerry A. Nicolaes, Willem J. M. Mulder, Christian Weber, Esther Lutgens^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

75 Citations (Web of Science)

Original language	English
Pages (from-to)	527-542
Number of pages	16
Journal	Journal of the American College of Cardiology
Volume	71
Issue number	5
DOIs	https://doi.org/10.1016/j.jacc.2017.11.055
Publication status	Published - 6 Feb 2018

Keywords

atherosclerosis
drug development
immunology
inflammation
nanotechnology
CD40-TRAF6 INTERACTIONS
IMMUNE-SYSTEM
MICE
CD40
INHIBITION
CELLS
ACTIVATION
PHENOTYPE
MECHANISM
THERAPY

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10.1016/j.jacc.2017.11.055

https://doi.org/10.1016/j.jacc.2017.11.055

Cite this

Seijkens, T. T. P., van Tiel, C. M., Kusters, P. J. H., Atzler, D., Soehnlein, O., Zarzycka, B., Aarts, S. A. B. M., Lameijer, M., Gijbels, M. J., Beckers, L., den Toom, M., Slutter, B., Kuiper, J., Duchene, J., Aslani, M., Megens, R. T. A., van 't Veer, C., Kooij, G., Schrijver, R., ... Lutgens, E. (2018). Targeting CD40-Induced TRAF6 Signaling in Macrophages Reduces Atherosclerosis. Journal of the American College of Cardiology, 71(5), 527-542. https://doi.org/10.1016/j.jacc.2017.11.055

Seijkens, Tom T. P. ; van Tiel, Claudia M. ; Kusters, Pascal J. H. ; Atzler, Dorothee ; Soehnlein, Oliver ; Zarzycka, Barbara ; Aarts, Suzanne A. B. M. ; Lameijer, Marnix ; Gijbels, Marion J. ; Beckers, Linda ; den Toom, Myrthe ; Slutter, Bram ; Kuiper, Johan ; Duchene, Johan ; Aslani, Maria ; Megens, Remco T. A. ; van 't Veer, Cornelis ; Kooij, Gijs ; Schrijver, Roy ; Hoeksema, Marten A. ; Boon, Louis ; Fay, Francois ; Tang, Jun ; Baxter, Samantha ; Jongejan, Aldo ; Moerland, Perry D. ; Vriend, Gert ; Bleijlevens, Boris ; Fisher, Edward A. ; Duivenvoorden, Raphael ; Gerdes, Norbert ; de Winther, Menno P. J. ; Nicolaes, Gerry A. ; Mulder, Willem J. M. ; Weber, Christian ; Lutgens, Esther. / Targeting CD40-Induced TRAF6 Signaling in Macrophages Reduces Atherosclerosis. In: Journal of the American College of Cardiology. 2018 ; Vol. 71, No. 5. pp. 527-542.

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title = "Targeting CD40-Induced TRAF6 Signaling in Macrophages Reduces Atherosclerosis",

keywords = "atherosclerosis, drug development, immunology, inflammation, nanotechnology, CD40-TRAF6 INTERACTIONS, IMMUNE-SYSTEM, MICE, CD40, INHIBITION, CELLS, ACTIVATION, PHENOTYPE, MECHANISM, THERAPY",

author = "Seijkens, {Tom T. P.} and {van Tiel}, {Claudia M.} and Kusters, {Pascal J. H.} and Dorothee Atzler and Oliver Soehnlein and Barbara Zarzycka and Aarts, {Suzanne A. B. M.} and Marnix Lameijer and Gijbels, {Marion J.} and Linda Beckers and {den Toom}, Myrthe and Bram Slutter and Johan Kuiper and Johan Duchene and Maria Aslani and Megens, {Remco T. A.} and {van 't Veer}, Cornelis and Gijs Kooij and Roy Schrijver and Hoeksema, {Marten A.} and Louis Boon and Francois Fay and Jun Tang and Samantha Baxter and Aldo Jongejan and Moerland, {Perry D.} and Gert Vriend and Boris Bleijlevens and Fisher, {Edward A.} and Raphael Duivenvoorden and Norbert Gerdes and {de Winther}, {Menno P. J.} and Nicolaes, {Gerry A.} and Mulder, {Willem J. M.} and Christian Weber and Esther Lutgens",

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Seijkens, TTP, van Tiel, CM, Kusters, PJH, Atzler, D, Soehnlein, O, Zarzycka, B, Aarts, SABM, Lameijer, M, Gijbels, MJ, Beckers, L, den Toom, M, Slutter, B, Kuiper, J, Duchene, J, Aslani, M, Megens, RTA, van 't Veer, C, Kooij, G, Schrijver, R, Hoeksema, MA, Boon, L, Fay, F, Tang, J, Baxter, S, Jongejan, A, Moerland, PD, Vriend, G, Bleijlevens, B, Fisher, EA, Duivenvoorden, R, Gerdes, N, de Winther, MPJ, Nicolaes, GA, Mulder, WJM, Weber, C & Lutgens, E 2018, 'Targeting CD40-Induced TRAF6 Signaling in Macrophages Reduces Atherosclerosis', Journal of the American College of Cardiology, vol. 71, no. 5, pp. 527-542. https://doi.org/10.1016/j.jacc.2017.11.055

Targeting CD40-Induced TRAF6 Signaling in Macrophages Reduces Atherosclerosis. / Seijkens, Tom T. P.; van Tiel, Claudia M.; Kusters, Pascal J. H.; Atzler, Dorothee; Soehnlein, Oliver; Zarzycka, Barbara; Aarts, Suzanne A. B. M.; Lameijer, Marnix; Gijbels, Marion J.; Beckers, Linda; den Toom, Myrthe; Slutter, Bram; Kuiper, Johan; Duchene, Johan; Aslani, Maria; Megens, Remco T. A.; van 't Veer, Cornelis; Kooij, Gijs; Schrijver, Roy; Hoeksema, Marten A.; Boon, Louis; Fay, Francois; Tang, Jun; Baxter, Samantha; Jongejan, Aldo; Moerland, Perry D.; Vriend, Gert; Bleijlevens, Boris; Fisher, Edward A.; Duivenvoorden, Raphael; Gerdes, Norbert; de Winther, Menno P. J.; Nicolaes, Gerry A.; Mulder, Willem J. M.; Weber, Christian; Lutgens, Esther.

In: Journal of the American College of Cardiology, Vol. 71, No. 5, 06.02.2018, p. 527-542.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Targeting CD40-Induced TRAF6 Signaling in Macrophages Reduces Atherosclerosis

AU - Seijkens, Tom T. P.

AU - van Tiel, Claudia M.

AU - Kusters, Pascal J. H.

AU - Atzler, Dorothee

AU - Soehnlein, Oliver

AU - Zarzycka, Barbara

AU - Aarts, Suzanne A. B. M.

AU - Lameijer, Marnix

AU - Gijbels, Marion J.

AU - Beckers, Linda

AU - den Toom, Myrthe

AU - Slutter, Bram

AU - Kuiper, Johan

AU - Duchene, Johan

AU - Aslani, Maria

AU - Megens, Remco T. A.

AU - van 't Veer, Cornelis

AU - Kooij, Gijs

AU - Schrijver, Roy

AU - Hoeksema, Marten A.

AU - Boon, Louis

AU - Fay, Francois

AU - Tang, Jun

AU - Baxter, Samantha

AU - Jongejan, Aldo

AU - Moerland, Perry D.

AU - Vriend, Gert

AU - Bleijlevens, Boris

AU - Fisher, Edward A.

AU - Duivenvoorden, Raphael

AU - Gerdes, Norbert

AU - de Winther, Menno P. J.

AU - Nicolaes, Gerry A.

AU - Mulder, Willem J. M.

AU - Weber, Christian

AU - Lutgens, Esther

PY - 2018/2/6

Y1 - 2018/2/6

KW - atherosclerosis

KW - drug development

KW - immunology

KW - inflammation

KW - nanotechnology

KW - CD40-TRAF6 INTERACTIONS

KW - IMMUNE-SYSTEM

KW - MICE

KW - CD40

KW - INHIBITION

KW - CELLS

KW - ACTIVATION

KW - PHENOTYPE

KW - MECHANISM

KW - THERAPY

U2 - 10.1016/j.jacc.2017.11.055

DO - 10.1016/j.jacc.2017.11.055

M3 - Article

C2 - 29406859

VL - 71

SP - 527

EP - 542

JO - Journal of the American College of Cardiology

JF - Journal of the American College of Cardiology

SN - 0735-1097

IS - 5

ER -