T cells in ANCA-associated vasculitis: what can we learn from lesional versus circulating T cells?

Benjamin Wilde, Marielle Thewissen, Jan Damoiseaux, Pieter van Paassen, Oliver Witzke, Jan Willem Cohen Tervaert*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

66 Citations (Web of Science)

Abstract

Anti-neutrophil cytoplasmic antibody (ANCA)associated vasculitis (AAV) is a life-threatening autoimmune disease characterized by an antibody mediated glomerulonephritis and necrotizing vasculitis. Apart from antibodies, T cells are also involved in disease pathogenesis. This review stresses the hallmarks of T cell-mediated pathology in AAV and highlights the characteristics of lesional and circulating T cells in the immune response in AAV. Circulating effector T-cell populations are expanded and are in a persistent state of activation. Circulating regulatory T-cell subsets are less well characterized but seem to be impaired in function. Lesional effector T cells are present in granulomas, vasculitic lesions, and nephritis. Lesional T cells usually show pro-inflammatory properties and promote granuloma formation. Apart from T cells, dendritic cells are abundantly present at the sites of inflammation and locally orchestrate the immune response. Targeting the above-mentioned T cell-mediated disease mechanisms will potentially provide powerful therapeutic tools for AAV.
Original languageEnglish
Pages (from-to)204
JournalArthritis Research & Therapy
Volume12
Issue number1
DOIs
Publication statusPublished - 2010

Cite this