Systemic markers of inflammation and cognitive decline in old age

M.T. Schram*, S.M. Euser, A.J. Craen, J.C.M. Witteman, M. Frolich, A. Hofman, J. Jolles, M.M. Breteler, R.G.J. Westendorp

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

676 Downloads (Pure)


OBJECTIVES: To investigate whether higher circulating levels of C-reactive protein (CRP), interleukin-6 (IL-6), and alpha 1-antichymotrypsin (ACT) are associated with worse cognitive function and decline in old age. DESIGN: Two independent population-based cohort studies. SETTING: The Rotterdam Study (mean follow-up 4.6 years) and the Leiden 85-plus Study (maximal follow-up 5 years). PARTICIPANTS: Three thousand eight hundred seventy-four individuals, mean age 72, from the Rotterdam Study, and 491 individuals, all aged 85, from the Leiden 85-plus Study. MEASUREMENTS: Both studies assessed global cognition, executive function, and memory. Linear regression analyses were used in the current study to investigate the associations between inflammatory markers and cognitive function and decline. RESULTS: In the Rotterdam Study, higher levels of CRP and IL-6 were cross-sectionally associated with worse global cognition and executive function (P
Original languageEnglish
Pages (from-to)708-16
JournalJournal of the American Geriatrics Society
Volume55 (5)
Publication statusPublished - 1 Jan 2007

Cite this