Systemic markers of inflammation and cognitive decline in old age

M.T. Schram; S.M. Euser; A.J. Craen; J.C.M. Witteman; M. Frolich; A. Hofman; J. Jolles; M.M. Breteler; R.G.J. Westendorp

doi:10.1111/j.1532-5415.2007.01159.x

Systemic markers of inflammation and cognitive decline in old age

M.T. Schram^*, S.M. Euser, A.J. Craen, J.C.M. Witteman, M. Frolich, A. Hofman, J. Jolles, M.M. Breteler, R.G.J. Westendorp

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

OBJECTIVES: To investigate whether higher circulating levels of C-reactive protein (CRP), interleukin-6 (IL-6), and alpha 1-antichymotrypsin (ACT) are associated with worse cognitive function and decline in old age. DESIGN: Two independent population-based cohort studies. SETTING: The Rotterdam Study (mean follow-up 4.6 years) and the Leiden 85-plus Study (maximal follow-up 5 years). PARTICIPANTS: Three thousand eight hundred seventy-four individuals, mean age 72, from the Rotterdam Study, and 491 individuals, all aged 85, from the Leiden 85-plus Study. MEASUREMENTS: Both studies assessed global cognition, executive function, and memory. Linear regression analyses were used in the current study to investigate the associations between inflammatory markers and cognitive function and decline. RESULTS: In the Rotterdam Study, higher levels of CRP and IL-6 were cross-sectionally associated with worse global cognition and executive function (P

Original language	English
Pages (from-to)	708-16
Journal	Journal of the American Geriatrics Society
Volume	55 (5)
DOIs	https://doi.org/10.1111/j.1532-5415.2007.01159.x
Publication status	Published - 1 Jan 2007

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title = "Systemic markers of inflammation and cognitive decline in old age",

abstract = "OBJECTIVES: To investigate whether higher circulating levels of C-reactive protein (CRP), interleukin-6 (IL-6), and alpha 1-antichymotrypsin (ACT) are associated with worse cognitive function and decline in old age. DESIGN: Two independent population-based cohort studies. SETTING: The Rotterdam Study (mean follow-up 4.6 years) and the Leiden 85-plus Study (maximal follow-up 5 years). PARTICIPANTS: Three thousand eight hundred seventy-four individuals, mean age 72, from the Rotterdam Study, and 491 individuals, all aged 85, from the Leiden 85-plus Study. MEASUREMENTS: Both studies assessed global cognition, executive function, and memory. Linear regression analyses were used in the current study to investigate the associations between inflammatory markers and cognitive function and decline. RESULTS: In the Rotterdam Study, higher levels of CRP and IL-6 were cross-sectionally associated with worse global cognition and executive function (P ",

author = "M.T. Schram and S.M. Euser and A.J. Craen and J.C.M. Witteman and M. Frolich and A. Hofman and J. Jolles and M.M. Breteler and R.G.J. Westendorp",

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T1 - Systemic markers of inflammation and cognitive decline in old age

AU - Schram, M.T.

AU - Euser, S.M.

AU - Craen, A.J.

AU - Witteman, J.C.M.

AU - Frolich, M.

AU - Hofman, A.

AU - Jolles, J.

AU - Breteler, M.M.

AU - Westendorp, R.G.J.

PY - 2007/1/1

Y1 - 2007/1/1

N2 - OBJECTIVES: To investigate whether higher circulating levels of C-reactive protein (CRP), interleukin-6 (IL-6), and alpha 1-antichymotrypsin (ACT) are associated with worse cognitive function and decline in old age. DESIGN: Two independent population-based cohort studies. SETTING: The Rotterdam Study (mean follow-up 4.6 years) and the Leiden 85-plus Study (maximal follow-up 5 years). PARTICIPANTS: Three thousand eight hundred seventy-four individuals, mean age 72, from the Rotterdam Study, and 491 individuals, all aged 85, from the Leiden 85-plus Study. MEASUREMENTS: Both studies assessed global cognition, executive function, and memory. Linear regression analyses were used in the current study to investigate the associations between inflammatory markers and cognitive function and decline. RESULTS: In the Rotterdam Study, higher levels of CRP and IL-6 were cross-sectionally associated with worse global cognition and executive function (P

AB - OBJECTIVES: To investigate whether higher circulating levels of C-reactive protein (CRP), interleukin-6 (IL-6), and alpha 1-antichymotrypsin (ACT) are associated with worse cognitive function and decline in old age. DESIGN: Two independent population-based cohort studies. SETTING: The Rotterdam Study (mean follow-up 4.6 years) and the Leiden 85-plus Study (maximal follow-up 5 years). PARTICIPANTS: Three thousand eight hundred seventy-four individuals, mean age 72, from the Rotterdam Study, and 491 individuals, all aged 85, from the Leiden 85-plus Study. MEASUREMENTS: Both studies assessed global cognition, executive function, and memory. Linear regression analyses were used in the current study to investigate the associations between inflammatory markers and cognitive function and decline. RESULTS: In the Rotterdam Study, higher levels of CRP and IL-6 were cross-sectionally associated with worse global cognition and executive function (P

U2 - 10.1111/j.1532-5415.2007.01159.x

DO - 10.1111/j.1532-5415.2007.01159.x

M3 - Article

SN - 0002-8614

VL - 55 (5)

SP - 708

EP - 716

JO - Journal of the American Geriatrics Society

JF - Journal of the American Geriatrics Society

ER -