TY - JOUR
T1 - Systematic Review
T2 - Contribution of the Gut Microbiome to the Volatile Metabolic Fingerprint of Colorectal Neoplasia
AU - van Vorstenbosch, Robert
AU - Cheng, Hao Ran
AU - Jonkers, Daisy
AU - Penders, John
AU - Schoon, Erik
AU - Masclee, Ad
AU - van Schooten, Frederik-Jan
AU - Smolinska, Agnieszka
AU - Mujagic, Zlatan
N1 - Funding Information:
The authors declare no conflict of interest related to the current study. Part of the work of DJ, outside the submitted work, has been financed by public private partnership grants of the Dutch Top Knowledge Institute (TKI) Agri&Food and Health Holland, by the Carbokinetics program as part of the NWO-CCC Partnership Program, by Organic A2B/Mothersfinest BV, and by EU/FP7 SysmedIBD/305563, BIOM/305479, Character/305676, and H2020 DisCOvERIE/848228. AS is assistant professor at Maastricht University and is an advisor at Owlstone Medical (Cambridge, UK), a breath-based medical company aiming for the non-invasive detection of diseases. ZM reports grants from MLDS, Niels Stensen Fellowship, ZonMw, and Galapagos, and has served as a speaker for Galapagos and as an advisor for Johnson & Johnson, all outside the submitted work.
Funding Information:
The present study was partly funded by the Airborne Biomarkers for Colorectal Cancer project within the program ERA-NET: Transscan-2, Joint Translational Call for Proposals 20216 on: “minimally and non-invasive methods for early detection and/or progression of cancer”, transscan-067, KE, no. ERA-NET TRANSSCAN/02.2018. This was a project funded by the European Commission under the EU framework Horizon2020 and was partly funded by an unrestricted research grant by Pentax Medical.
Publisher Copyright:
© 2022 by the authors.
PY - 2023/1
Y1 - 2023/1
N2 - Colorectal cancer (CRC) has been associated with changes in volatile metabolic profiles in several human biological matrices. This enables its non-invasive detection, but the origin of these volatile organic compounds (VOCs) and their relation to the gut microbiome are not yet fully understood. This systematic review provides an overview of the current understanding of this topic. A systematic search using PubMed, Embase, Medline, Cochrane Library, and the Web of Science according to PRISMA guidelines resulted in seventy-one included studies. In addition, a systematic search was conducted that identified five systematic reviews from which CRC-associated gut microbiota data were extracted. The included studies analyzed VOCs in feces, urine, breath, blood, tissue, and saliva. Eight studies performed microbiota analysis in addition to VOC analysis. The most frequently reported dysregulations over all matrices included short-chain fatty acids, amino acids, proteolytic fermentation products, and products related to the tricarboxylic acid cycle and Warburg metabolism. Many of these dysregulations could be related to the shifts in CRC-associated microbiota, and thus the gut microbiota presumably contributes to the metabolic fingerprint of VOC in CRC. Future research involving VOCs analysis should include simultaneous gut microbiota analysis.
AB - Colorectal cancer (CRC) has been associated with changes in volatile metabolic profiles in several human biological matrices. This enables its non-invasive detection, but the origin of these volatile organic compounds (VOCs) and their relation to the gut microbiome are not yet fully understood. This systematic review provides an overview of the current understanding of this topic. A systematic search using PubMed, Embase, Medline, Cochrane Library, and the Web of Science according to PRISMA guidelines resulted in seventy-one included studies. In addition, a systematic search was conducted that identified five systematic reviews from which CRC-associated gut microbiota data were extracted. The included studies analyzed VOCs in feces, urine, breath, blood, tissue, and saliva. Eight studies performed microbiota analysis in addition to VOC analysis. The most frequently reported dysregulations over all matrices included short-chain fatty acids, amino acids, proteolytic fermentation products, and products related to the tricarboxylic acid cycle and Warburg metabolism. Many of these dysregulations could be related to the shifts in CRC-associated microbiota, and thus the gut microbiota presumably contributes to the metabolic fingerprint of VOC in CRC. Future research involving VOCs analysis should include simultaneous gut microbiota analysis.
U2 - 10.3390/metabo13010055
DO - 10.3390/metabo13010055
M3 - (Systematic) Review article
C2 - 36676980
SN - 2218-1989
VL - 13
JO - Metabolites
JF - Metabolites
IS - 1
M1 - 55
ER -