Synthesis of acylglycerol derivatives by mechanochemistry

Karen J. Ardila-Fierro; Andrij Pich; Marc Spehr; Jose G. Hernandez; Carsten Bolm

doi:10.3762/bjoc.15.78

Synthesis of acylglycerol derivatives by mechanochemistry

Karen J. Ardila-Fierro, Andrij Pich, Marc Spehr, Jose G. Hernandez^*, Carsten Bolm^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

In recent times, many biologically relevant building blocks such as amino acids, peptides, saccharides, nucleotides and nucleosides, etc. have been prepared by mechanochemical synthesis. However, mechanosynthesis of lipids by ball milling techniques has remained essentially unexplored. In this work, a multistep synthetic route to access mono- and diacylglycerol derivatives by mechanochemistry has been realized, including the synthesis of diacylglycerol-coumarin conjugates.

Original language	English
Pages (from-to)	811-817
Number of pages	7
Journal	Beilstein Journal of Organic Chemistry
Volume	15
DOIs	https://doi.org/10.3762/bjoc.15.78
Publication status	Published - 29 Mar 2019

Keywords

ball mill
coumarin
diacylglycerols
lipids
mechanochemistry
SOLVENT-FREE SYNTHESIS
ASYMMETRIC CATALYSIS
KINETIC RESOLUTION
TERMINAL EPOXIDES
PEPTIDE
ACTIVATION
EXTRUSION
COMPLEXES
MULTISTEP
PROTEINS

Access to Document

10.3762/bjoc.15.78Licence: CC BY

Cite this

@article{7f235ec3500f454a9bdda5fe270eadd6,

title = "Synthesis of acylglycerol derivatives by mechanochemistry",

abstract = "In recent times, many biologically relevant building blocks such as amino acids, peptides, saccharides, nucleotides and nucleosides, etc. have been prepared by mechanochemical synthesis. However, mechanosynthesis of lipids by ball milling techniques has remained essentially unexplored. In this work, a multistep synthetic route to access mono- and diacylglycerol derivatives by mechanochemistry has been realized, including the synthesis of diacylglycerol-coumarin conjugates.",

keywords = "ball mill, coumarin, diacylglycerols, lipids, mechanochemistry, SOLVENT-FREE SYNTHESIS, ASYMMETRIC CATALYSIS, KINETIC RESOLUTION, TERMINAL EPOXIDES, PEPTIDE, ACTIVATION, EXTRUSION, COMPLEXES, MULTISTEP, PROTEINS",

author = "Ardila-Fierro, {Karen J.} and Andrij Pich and Marc Spehr and Hernandez, {Jose G.} and Carsten Bolm",

year = "2019",

month = mar,

day = "29",

doi = "10.3762/bjoc.15.78",

language = "English",

volume = "15",

pages = "811--817",

journal = "Beilstein Journal of Organic Chemistry",

issn = "1860-5397",

publisher = "Beilstein-Institut Zur Forderung der Chemischen Wissenschaften",

}

TY - JOUR

T1 - Synthesis of acylglycerol derivatives by mechanochemistry

AU - Ardila-Fierro, Karen J.

AU - Pich, Andrij

AU - Spehr, Marc

AU - Hernandez, Jose G.

AU - Bolm, Carsten

PY - 2019/3/29

Y1 - 2019/3/29

N2 - In recent times, many biologically relevant building blocks such as amino acids, peptides, saccharides, nucleotides and nucleosides, etc. have been prepared by mechanochemical synthesis. However, mechanosynthesis of lipids by ball milling techniques has remained essentially unexplored. In this work, a multistep synthetic route to access mono- and diacylglycerol derivatives by mechanochemistry has been realized, including the synthesis of diacylglycerol-coumarin conjugates.

AB - In recent times, many biologically relevant building blocks such as amino acids, peptides, saccharides, nucleotides and nucleosides, etc. have been prepared by mechanochemical synthesis. However, mechanosynthesis of lipids by ball milling techniques has remained essentially unexplored. In this work, a multistep synthetic route to access mono- and diacylglycerol derivatives by mechanochemistry has been realized, including the synthesis of diacylglycerol-coumarin conjugates.

KW - ball mill

KW - coumarin

KW - diacylglycerols

KW - lipids

KW - mechanochemistry

KW - SOLVENT-FREE SYNTHESIS

KW - ASYMMETRIC CATALYSIS

KW - KINETIC RESOLUTION

KW - TERMINAL EPOXIDES

KW - PEPTIDE

KW - ACTIVATION

KW - EXTRUSION

KW - COMPLEXES

KW - MULTISTEP

KW - PROTEINS

U2 - 10.3762/bjoc.15.78

DO - 10.3762/bjoc.15.78

M3 - Article

SN - 1860-5397

VL - 15

SP - 811

EP - 817

JO - Beilstein Journal of Organic Chemistry

JF - Beilstein Journal of Organic Chemistry

ER -