Synthesis and In Vitro (Anticancer) Evaluation of eta(6)-Arene Ruthenium Complexes Bearing Stannyl Ligands

Olivier Renier, Connor Deacon-Price, Joannes E. B. Peters, Kunsulu Nurekeyeva, Catherine Russon, Simba Dyson, Siyabonga Ngubane, Judith Baumgartner, Paul J. Dyson, Tina Riedel, Haleden Chiririwa, Burgert Blom*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

Treatment of the known half-sandwich complexes of the type [(eta(6)-C6H6)RuCl2(P(OR)(3))] (R = Me or Ph) with SnCl2 yielded three new half-sandwich ruthenium complexes (C1-C3): [(eta(6)-C6H6)RuCl(SnCl3)(P(OMe)(3))] (C1), [(eta(6)-C6H6)RuCl(SnCl3)(P(OPh)(3))] (C2) and the bis-stannyl complex [(eta(6)-C6H6)Ru(SnCl3)(2)(P(OMe)(3))] (C3) by facile insertion of SnCl2 into the Ru-Cl bonds. Treatment of the known complexes [(eta(6)-C6H6)RuCl(SnCl3)(PPh3)] and [(eta(6)-C6H6)RuCl2(PPh3)] with 4-dimethylaminopyridine (DAMP) and ammonium tetrafluoroborate afforded the complex salts: [(eta(6)-C6H6)Ru(SnCl3)(PPh3)(DAMP)]+BF4- (C4) and [(eta(6)-C6H6)RuCl(PPh3)(DAMP)]+BF4- (C5) respectively. Complexes C1-C5 have been fully characterized by spectroscopic means (IR, UV-vis, multinuclear NMR, ESI-MS) and their thermal behaviour elucidated by thermal gravimetric analysis (TGA). Structural characterization by single crystal X-ray crystallography of the novel complex C2 and [(eta(6)-C6H6)RuCl2(P(OPh)(3))], the latter having escaped elucidation by this method, is also reported. Finally, the cytotoxicity of the complexes was determined on the A2780 (human ovarian cancer), A2780cisR (human ovarian cis-platin-resistant cancer), and the HEK293 (human embryonic kidney) cell lines and discussed, and an attempt is made to elucidate the effect of the stannyl ligand on cytotoxicity.

Original languageEnglish
Article number44
Number of pages13
JournalInorganics
Volume5
Issue number3
DOIs
Publication statusPublished - Sep 2017

Keywords

  • bioorganometallic chemistry
  • metal-based drugs
  • phosphorus ligands
  • ruthenium
  • half-sandwich complexes
  • tin dichloride insertion
  • PLATINUM COMPLEXES
  • METAL-COMPLEXES
  • CANCER
  • CHEMISTRY
  • DRUGS
  • CYTOTOXICITY
  • METALLODRUGS
  • DESIGN
  • KP1019
  • AGENTS

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