Synaptic Energy Use and Supply

Julia J. Harris; Renaud Jolivet; David Attwell

doi:10.1016/j.neuron.2012.08.019

Synaptic Energy Use and Supply

Julia J. Harris, Renaud Jolivet, David Attwell^*

^*Corresponding author for this work

Research output: Contribution to journal › (Systematic) Review article › peer-review

Abstract

Neuronal computation is energetically expensive. Consequently, the brain's limited energy supply imposes constraints on its information processing capability. Most brain energy is used on synaptic transmission, making it important to understand how energy is provided to and used by synapses. We describe how information transmission through presynaptic terminals and postsynaptic spines is related to their energy consumption, assess which mechanisms normally ensure an adequate supply of ATP to these structures, consider the influence of synaptic plasticity and changing brain state on synaptic energy use, and explain how disruption of the energy supply to synapses leads to neuropathology.

Original language	English
Pages (from-to)	762-777
Number of pages	16
Journal	Neuron
Volume	75
Issue number	5
DOIs	https://doi.org/10.1016/j.neuron.2012.08.019
Publication status	Published - 6 Sept 2012
Externally published	Yes

Keywords

CEREBRAL-BLOOD-FLOW
AMYOTROPHIC-LATERAL-SCLEROSIS
MITOCHONDRIAL TRAFFICKING
OXIDATIVE-PHOSPHORYLATION
EXCITATORY SYNAPSES
METABOLIC EFFICIENCY
GLUCOSE CONSUMPTION
OXYGEN-CONSUMPTION
MAMMALIAN NEURONS
ACTION-POTENTIALS

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title = "Synaptic Energy Use and Supply",

abstract = "Neuronal computation is energetically expensive. Consequently, the brain's limited energy supply imposes constraints on its information processing capability. Most brain energy is used on synaptic transmission, making it important to understand how energy is provided to and used by synapses. We describe how information transmission through presynaptic terminals and postsynaptic spines is related to their energy consumption, assess which mechanisms normally ensure an adequate supply of ATP to these structures, consider the influence of synaptic plasticity and changing brain state on synaptic energy use, and explain how disruption of the energy supply to synapses leads to neuropathology.",

keywords = "CEREBRAL-BLOOD-FLOW, AMYOTROPHIC-LATERAL-SCLEROSIS, MITOCHONDRIAL TRAFFICKING, OXIDATIVE-PHOSPHORYLATION, EXCITATORY SYNAPSES, METABOLIC EFFICIENCY, GLUCOSE CONSUMPTION, OXYGEN-CONSUMPTION, MAMMALIAN NEURONS, ACTION-POTENTIALS",

author = "Harris, {Julia J.} and Renaud Jolivet and David Attwell",

year = "2012",

month = sep,

day = "6",

doi = "10.1016/j.neuron.2012.08.019",

language = "English",

volume = "75",

pages = "762--777",

journal = "Neuron",

issn = "0896-6273",

publisher = "Cell Press",

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TY - JOUR

T1 - Synaptic Energy Use and Supply

AU - Harris, Julia J.

AU - Jolivet, Renaud

AU - Attwell, David

PY - 2012/9/6

Y1 - 2012/9/6

N2 - Neuronal computation is energetically expensive. Consequently, the brain's limited energy supply imposes constraints on its information processing capability. Most brain energy is used on synaptic transmission, making it important to understand how energy is provided to and used by synapses. We describe how information transmission through presynaptic terminals and postsynaptic spines is related to their energy consumption, assess which mechanisms normally ensure an adequate supply of ATP to these structures, consider the influence of synaptic plasticity and changing brain state on synaptic energy use, and explain how disruption of the energy supply to synapses leads to neuropathology.

AB - Neuronal computation is energetically expensive. Consequently, the brain's limited energy supply imposes constraints on its information processing capability. Most brain energy is used on synaptic transmission, making it important to understand how energy is provided to and used by synapses. We describe how information transmission through presynaptic terminals and postsynaptic spines is related to their energy consumption, assess which mechanisms normally ensure an adequate supply of ATP to these structures, consider the influence of synaptic plasticity and changing brain state on synaptic energy use, and explain how disruption of the energy supply to synapses leads to neuropathology.

KW - CEREBRAL-BLOOD-FLOW

KW - AMYOTROPHIC-LATERAL-SCLEROSIS

KW - MITOCHONDRIAL TRAFFICKING

KW - OXIDATIVE-PHOSPHORYLATION

KW - EXCITATORY SYNAPSES

KW - METABOLIC EFFICIENCY

KW - GLUCOSE CONSUMPTION

KW - OXYGEN-CONSUMPTION

KW - MAMMALIAN NEURONS

KW - ACTION-POTENTIALS

U2 - 10.1016/j.neuron.2012.08.019

DO - 10.1016/j.neuron.2012.08.019

M3 - (Systematic) Review article

SN - 0896-6273

VL - 75

SP - 762

EP - 777

JO - Neuron

JF - Neuron

IS - 5

ER -

Synaptic Energy Use and Supply

Abstract

Keywords

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