Abstract

This study determines the relationship between patient and investigator reported outcome measures (PROMs versus IROMs) on oropharyngeal dysphagia (OD) in Parkinson's disease (PD). The PROMs used are the MD Anderson Dysphagia Inventory (MDADI) and the Dysphagia Severity Scale (DSS). The IROMs used are fiberoptic endoscopic evaluation of swallowing (FEES) and videofluoroscopy of swallowing (VFS). Ninety dysphagic PD patients were included. Multilayer perceptron (MLP) neural network analysis was used to investigate the relationship between PROMs and IROMs on OD in PD. MLP neural network analysis showed a moderate agreement between PROMs and IROMs, with an area under the curve between 0.6 and 0.7. Two-step cluster analysis revealed several clusters of patients with similar scores on FEES and/or VFS variables, but with significant different scores on MDADI and DSS variables. This study highlights that there are PD patients with similar FEES and/or VFS findings that cannot be lumped together under the same pathophysiological umbrella due to their differences in PROMs. Since the exact origin of these differences is not fully understood, it seems appropriate for the time being to take into account the different dimensions of OD during the swallowing assessment so that they can be included in a patient-tailored treatment plan.

Original languageEnglish
Pages (from-to)864-874
Number of pages11
JournalDysphagia
Volume36
Issue number5
Early online date31 Oct 2020
DOIs
Publication statusPublished - Oct 2021

Keywords

  • Oropharyngeal dysphagia
  • Parkinson&apos
  • s disease
  • Patient reported outcome measures
  • Investigator reported outcome measures
  • Neural network analysis
  • QUALITY-OF-LIFE
  • FIBEROPTIC ENDOSCOPIC EVALUATION
  • OROPHARYNGEAL DYSPHAGIA
  • ASPIRATION
  • STIMULATION
  • PROGRESSION
  • MANAGEMENT

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