Sunlight exposure is just one of the factors which influence vitamin D status

M. Abboud, M. S. Rybchyn, R. Rizk, D. R. Frasere, R. S. Mason*

*Corresponding author for this work

Research output: Contribution to journal(Systematic) Review article peer-review

25 Citations (Web of Science)

Abstract

Studies on the determinants of vitamin D status have tended to concentrate on input - exposure to ultraviolet B radiation and the limited sources in food. Yet, vitamin D status, determined by circulating concentrations of 25-hydroxyvitamin D (25(OH) D), can vary quite markedly in groups of people with apparently similar inputs of vitamin D. There are small effects of polymorphisms in the genes for key proteins involved in vitamin D production and metabolism, including 7-dehydrocholesterol reductase, which converts 7-dehydrocholesterol, the precursor of vitamin D, to cholesterol, CYP2R1, the main 25-hydroxylase of vitamin D, GC, coding for the vitamin D binding protein which transports 25(OH) D and other meta-bolites in blood and CYP24A1, which 24-hydroxylates both 25(OH) D and the hormone, 1,25-dihydroxyvitamin D. 25(OH) D has a highly variable half-life in blood. There is evidence that the half-life of 25(OH) D is affected by calcium intake and some therapeutic agents. Fat tissue seems to serve as a sink for the parent vitamin D, which is released mainly when there are reductions in adiposity. Some evidence is presented to support the proposal that skeletal muscle provides a substantial site of sequestration of 25(OH) D, protecting this metabolite from degradation by the liver, which may help to explain why exercise, not just outdoors, is usually associated with better vitamin D status.

Original languageEnglish
Pages (from-to)302-313
Number of pages12
JournalPhotochemical & Photobiological Sciences
Volume16
Issue number3
DOIs
Publication statusPublished - 1 Mar 2017

Keywords

  • D-BINDING PROTEIN
  • RANDOMIZED CONTROLLED-TRIAL
  • DRUG-INDUCED OSTEOMALACIA
  • 25-HYDROXYVITAMIN D 25OHD
  • GENOME-WIDE ASSOCIATION
  • D DEFICIENCY
  • SKELETAL-MUSCLE
  • GC-GLOBULIN
  • ANTICONVULSANT DRUGS
  • CALCIUM-METABOLISM

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