Abstract
Purpose Investigate in patients with metastatic and/or irresectable colorectal cancer treated with systemic treatment with capecitabine or TAS-102 whether: 1. Intestinal microbiota composition can act as a predictor for response. 2. Intestinal microbiota composition changes during systemic treatment and its relation to chemotoxicity. Background Gut microbiota and host determinants evolve in symbiotic and dependent relationships resulting in a personal ecosystem. In vitro studies showed prolonged and increased response to 5-fluorouracil, a fluoropyrimidine, in the presence of a favorable microbiota composition. Capecitabine and TAS-102 are both fluoropyrimidines used for systemic treatment in colorectal cancer patients. Methods An explorative prospective multicenter cohort study in the Maastricht University Medical Centre+ and Zuyderland Medical Centre will be performed in 66 patients. Before, during, and after three cycles of systemic treatment with capecitabine or TAS-102, fecal samples and questionnaires (concerning compliance and chemotoxicity) will be collected. The response will be measured by CT/ MRI using RECIST-criteria. Fecal microbiota composition will be analyzed with 16S rRNA next-generation sequencing. The absolute bacterial abundance will be assessed with quantitative polymerase chain reaction. Multivariate analysis will be used for statistical analysis. Conclusions We aim to detect a microbiota composition that predicts if patients with metastatic and/ or irresectable colorectal cancer will respond to systemic treatment and/ or experience zero to limited chemotoxicity. If we are able to identify a favorable microbiota composition, fecal microbiota transplantation might be the low-burden alternative to chemotherapy switch in the future.
Original language | English |
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Pages (from-to) | 1077-1084 |
Number of pages | 8 |
Journal | International Journal of Colorectal Disease |
Volume | 32 |
Issue number | 7 |
DOIs | |
Publication status | Published - Jul 2017 |
Keywords
- Intestinal microbiota
- Colorectal cancer treatment
- RANDOMIZED-TRIAL
- CAPECITABINE
- CARCINOGENESIS
- FLUOROURACIL
- CHEMOTHERAPY