Structural predictions of neurobiologically relevant G-protein coupled receptors and intrinsically disordered proteins

Giulia Rossetti, Menica Dibenedetto, Vania Calandrini, Alejandro Giorgetti*, Paolo Carloni

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Web of Science)


G protein coupled receptors (GPCRs) and intrinsic disordered proteins (IDPs) are key players for neuronal function and dysfunction. Unfortunately, their structural characterization is lacking in most cases. From one hand, no experimental structure has been determined for the two largest GPCRs subfamilies, both key proteins in neuronal pathways. These are the odorant (450 members out of 900 human GPCRs) and the bitter taste receptors (25 members) subfamilies. On the other hand, also IDPs structural characterization is highly non-trivial. They exist as dynamic, highly flexible structural ensembles that undergo conformational conversions on a wide range of timescales, spanning from picoseconds to milliseconds. Computational methods may be of great help to characterize these neuronal proteins. Here we review recent progress from our lab and other groups to develop and apply in silico methods for structural predictions of these highly relevant, fascinating and challenging systems.
Original languageEnglish
Pages (from-to)91-100
JournalArchives of Biochemistry and Biophysics
Publication statusPublished - 15 Sept 2015
Externally publishedYes


  • G-protein coupled receptors
  • Intrinsic disordered proteins
  • Computational biophysics
  • Bioinformatics

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