Specific Genetic Influences on Nighttime Blood Pressure

X. Xu, S. Su, F.A. Treiber, R. Vlietinck, R. Fagard, C. Derom, Marij GIelen, R.J.F. Loos, H. Snieder, X. Wang

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Abstract

OBJECTIVES

Nighttime blood pressure (BP) has been shown to be superior to daytime BP in predicting hypertension related target organ damage and cardiac mortality. In our Georgia Cardiovascular Twin Study, we showed that apart from the genes that also influence daytime BP, specific genetic determinants explained 44% and 67% of the nighttime systolic BP (SBP) and diastolic BP (DBP) heritabilities, respectively. Here, we determined whether these results could be confirmed in a much larger twin cohort of young adults with 24-hour ambulatory BP measurements.

METHODS

Ambulatory BP was available in 703 white twins (308 pairs and 87 singletons, aged 18-34 years, 50% males) from the Prenatal Programming Twin Study. A bivariate quantitative genetic twin model was used to analyze daytime and nighttime BP. We conducted a meta-analysis to compare and integrate results from the 2 twin cohorts.

RESULTS

Model fitting showed no sex differences for any of the measures. Heritabilities were 0.60 and 0.51 for SBP and 0.54 and 0.46 for DBP at daytime and nighttime. The specific heritability due to novel genetic effects emerging during the nighttime was 0.21 for SBP and 0.26 for DBP, which comprised 41% and 57% of the total nighttime heritability for SBP and DBP, respectively. Meta-analysis confirmed absence of cohort differences with very similar combined results.

CONCLUSIONS

In addition to genes that influence both daytime and nighttime BP, a large part of the heritability is explained by genes that specifically influence BP at night.

Original languageEnglish
Pages (from-to)440-443
Number of pages4
JournalAmerican Journal of Hypertension
Volume28
Issue number4
DOIs
Publication statusPublished - Apr 2015

Keywords

  • nighttime blood pressure
  • heritability
  • meta-analysis
  • twin study
  • HYPERTENSION
  • DAYTIME
  • TWINS

Cite this

Xu, X., Su, S., Treiber, F. A., Vlietinck, R., Fagard, R., Derom, C., GIelen, M., Loos, R. J. F., Snieder, H., & Wang, X. (2015). Specific Genetic Influences on Nighttime Blood Pressure. American Journal of Hypertension, 28(4), 440-443. https://doi.org/10.1093/ajh/hpu162