Spatiotemporal Activation Time Estimation Improves Noninvasive Localization of Cardiac Electrical Activity

Matthijs Cluitmans*, Jaume Coll-Font, Dana Brooks, Burak Erem, Pietro Bonizzi, Joël Karel, Paul Volders, Ralf Peeters, Ronald Westra

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference article in proceedingAcademicpeer-review

2 Citations (Web of Science)


Electrocardiographic imaging (ECGI) reconstructs epicardial potentials and electrograms from body-surface electrocardiograms and a torso-heart geometry. For clinical purposes, local activation and recovery times are often more useful than epicardial electrograms. However, noise and fractionation can affect estimation of activation and recovery times from reconstructed electrograms. Here, we employ a method for activation and recovery time estimation that detects the simultaneous presence of spatial and temporal features associated with a passing wavefront and evaluate this in a series of canine experiments. We show that estimation of activation times is more accurate when this spatiotemporal approach is used, however, recovery times are best determined with a temporal-only approach. Additional spatial smoothing further benefits activation and recovery time estimation in all cases. This results in a median beat origin localization error of only one centimeter, which could expedite catheter-based diagnostic evaluation and ablation in clinical settings.
Original languageEnglish
Title of host publicationComputing in Cardiology
Place of PublicationVancouver, Canada
Number of pages4
ISBN (Print)9781509008957
Publication statusPublished - 1 Sep 2016
Event43rd Computing in Cardiology Conference (CinC) - Vancouver, Canada
Duration: 11 Sep 201614 Sep 2016

Publication series

SeriesComputing in Cardiology Conference


Conference43rd Computing in Cardiology Conference (CinC)
Abbreviated title CinC 2016
Internet address


  • Joint WG e-Cardiology ESC – CinC: Clinical Needs Translational Award (CTA)

    Cluitmans, Matthijs (Recipient), Coll-Font, Jaume (Recipient), Erem, Burak (Recipient), Brooks, Dana (Recipient), Bonizzi, Pietro (Recipient), Karel, Joël (Recipient), Volders, Paul (Recipient), Peeters, Ralf (Recipient) & Westra, Ronald (Recipient), 14 Sep 2016

    Prize: Prize (including medals and awards)Academic

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