Sources of auditory selective attention and the effects of MPH in children with ADHD

C. Kemner*, L.M. Jonkman, J.L. Kenemans, M.N. Verbaten, H. van Engeland

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

57 Downloads (Pure)


The aim of this study was to determine 1) whether abnormal auditory selective attention in children with attention-deficit/hyperactivity disorder (ADHD), as reflected in the processing negativity (PN) of the event-related potential, is related to impaired frontal functioning; and 2) how methylphenidate (MPh) affects attentional functioning in ADHD.Sources of electrical brain activity were estimated in healthy control children, in ADHD children without medication, and in children with ADHD during a placebo-controlled medication trial involving MPh.The source models showed that the PN is generated in the auditory cortex. Children with ADHD showed less activity related to selective attention in this brain region. Administration of MPh resulted in more frontally located sources.The results showed no evidence for an important role of the frontal cortex in abnormalities in selective attention in children with ADHD. Also, the data did not indicate that MPh normalizes brain activity in these children.
Original languageEnglish
Pages (from-to)776-778
JournalBiological Psychiatry
Issue number7
Publication statusPublished - 1 Jan 2004


Dive into the research topics of 'Sources of auditory selective attention and the effects of MPH in children with ADHD'. Together they form a unique fingerprint.

Cite this