TY - JOUR
T1 - Smart and bioinspired systems for overcoming biological barriers and enhancing disease theranostics
AU - Li, Xin
AU - Gao, Yue
AU - Li, Helin
AU - Majoral, Jean Pierre
AU - Shi, Xiangyang
AU - Pich, Andrij
N1 - Funding Information:
X. Li and Y. Gao contributed equally to this work. This work was financially supported by the Sino-German Center for Research Promotion ( GZ1505 ), DFG ( SFB 985 , Functional Microgels and Microgel Systems), National Natural Science Foundation of China ( 81761148028 ), Natural Science Foundation of Zhejiang Province ( LTGY23B040001 ), Science and Technology Commission of Shanghai Municipality ( 19XD1400100 ), and China Scholarship Council (for X. Li).
Publisher Copyright:
© 2023 Elsevier Ltd
PY - 2023/12/1
Y1 - 2023/12/1
N2 - Nanomedicine has emerged as a promising mean to improve theranostic efficacy and reduce side effects. Currently, only very small percentage of injected dose reaches the solid tumors after intravenous administration due to the systemic biological barriers, including blood circulation, reticuloendothelial system capture, vasculature extravasation, tissue accumulation, deep penetration, cellular internalization, lysosome escape, intracellular efflux, and cell nuclear targeting. To optimize clinical translation and exploitation of nanomedicine, we here propose three safe and effective strategies to systematically overcome all barriers by the novel design of smart and bioinspired systems for highly efficient theranostics of various diseases, such as cancers, neurodegenerations, myocardial infarctions, inflammations, and infections. (1) Surface charge conversion, (2) size transformation, (3) bioinspired systems display unprecedented potential to achieve higher requirement of precise and personalized medicine. Alone or specially together, these strategies can address different barriers with intrinsically conflicting and promote the development of successful disease theranostics, that is impossible for almost of conventional delivery systems. Moreover, the challenges and perspectives of next-generation smart nanomedicine are featured for accurate theranostics and clinical practice in various diseases.
AB - Nanomedicine has emerged as a promising mean to improve theranostic efficacy and reduce side effects. Currently, only very small percentage of injected dose reaches the solid tumors after intravenous administration due to the systemic biological barriers, including blood circulation, reticuloendothelial system capture, vasculature extravasation, tissue accumulation, deep penetration, cellular internalization, lysosome escape, intracellular efflux, and cell nuclear targeting. To optimize clinical translation and exploitation of nanomedicine, we here propose three safe and effective strategies to systematically overcome all barriers by the novel design of smart and bioinspired systems for highly efficient theranostics of various diseases, such as cancers, neurodegenerations, myocardial infarctions, inflammations, and infections. (1) Surface charge conversion, (2) size transformation, (3) bioinspired systems display unprecedented potential to achieve higher requirement of precise and personalized medicine. Alone or specially together, these strategies can address different barriers with intrinsically conflicting and promote the development of successful disease theranostics, that is impossible for almost of conventional delivery systems. Moreover, the challenges and perspectives of next-generation smart nanomedicine are featured for accurate theranostics and clinical practice in various diseases.
KW - Bioinspired systems
KW - Biological barriers
KW - Nanotheranostics
KW - Smart nanocarriers
KW - Tumor delivery mechanism
U2 - 10.1016/j.pmatsci.2023.101170
DO - 10.1016/j.pmatsci.2023.101170
M3 - (Systematic) Review article
SN - 0079-6425
VL - 140
JO - Progress in Materials Science
JF - Progress in Materials Science
M1 - 101170
ER -