TY - JOUR
T1 - Small intestine vs. colon ecology and physiology
T2 - Why it matters in probiotic administration
AU - Jensen, Benjamin Anderschou Holbech
AU - Heyndrickx, Marc
AU - Jonkers, Daisy
AU - Mackie, Alan
AU - Millet, Sam
AU - Naghibi, Malwina
AU - Pærregaard, Simone Isling
AU - Pot, Bruno
AU - Saulnier, Delphine
AU - Sina, Christian
AU - Sterkman, Luc Gerardus Willibrordus
AU - Van den Abbeele, Pieter
AU - Venlet, Naomi Vita
AU - Zoetendal, Erwin G.
AU - Ouwehand, Arthur Constantijn
N1 - Funding Information:
This work was conducted by an expert group (EG) of ILSI Europe. Composition of the EG is listed on the ILSI Europe website at https://ilsi.eu/scientific-activities/nutrition/probiotics/. ILSI Europe facilitated scientific meetings and coordinated the overall project management and administrative tasks relating to the completion of this work. This manuscript was copy edited by Cath Mersh. Traveling and accommodation expenses were covered by ILSI Europe. All authors contributed to design and writing of the first manuscript draft. B.A.H.J. and A.C.O. led the process of editing and contextualizing the body text while integrating the contributions of each individual author. B.A.H.J. was responsible for the final editing of the manuscript. First and last authors are positioned according to standard guidelines. Remaining authors are ordered alphabetically, emphasizing the joint effort. A.C.O. M.N. B.P. D.S. L.G.W.S. and P.V.D.A. work full time for IFF, ADM, Yakult, Novozymes, Caelus Health, and Cryptobiotix respectively. These companies were not involved in carrying out this research.
Publisher Copyright:
© 2023 The Authors
PY - 2023/9/19
Y1 - 2023/9/19
N2 - Research on gut microbiota has generally focused on fecal samples, representing luminal content of the large intestine. However, nutrient uptake is restricted to the small intestine. Abundant immune cell populations at this anatomical site combined with diminished mucus secretion and looser junctions (partly to allow for more efficient fluid and nutrient absorption) also results in intimate host-microbe interactions despite more rapid transit. It is thus crucial to dissect key differences in both ecology and physiology between small and large intestine to better leverage the immense potential of human gut microbiota imprinting, including probiotic engraftment at biological sensible niches. Here, we provide a detailed review unfolding how the physiological and anatomical differences between the small and large intestine affect gut microbiota composition, function, and plasticity. This information is key to understanding how gut microbiota manipulation, including probiotic administration, may strain-dependently transform host-microbe interactions at defined locations.
AB - Research on gut microbiota has generally focused on fecal samples, representing luminal content of the large intestine. However, nutrient uptake is restricted to the small intestine. Abundant immune cell populations at this anatomical site combined with diminished mucus secretion and looser junctions (partly to allow for more efficient fluid and nutrient absorption) also results in intimate host-microbe interactions despite more rapid transit. It is thus crucial to dissect key differences in both ecology and physiology between small and large intestine to better leverage the immense potential of human gut microbiota imprinting, including probiotic engraftment at biological sensible niches. Here, we provide a detailed review unfolding how the physiological and anatomical differences between the small and large intestine affect gut microbiota composition, function, and plasticity. This information is key to understanding how gut microbiota manipulation, including probiotic administration, may strain-dependently transform host-microbe interactions at defined locations.
U2 - 10.1016/j.xcrm.2023.101190
DO - 10.1016/j.xcrm.2023.101190
M3 - (Systematic) Review article
SN - 2666-3791
VL - 4
JO - Cell Reports Medicine
JF - Cell Reports Medicine
IS - 9
M1 - 101190
ER -