Skin of atopic dermatitis patients shows disturbed beta-glucocerebrosidase and acid sphingomyelinase activity that relates to changes in stratum corneum lipid composition

Daphne E. C. Boer, Jeroen van Smeden, Hanin Al-Khakany, Elizaveta Melnik, Rianne van Dijk, Samira Absalah, Rob J. Vreeken, Caroline C. P. Haenen, Adriana P. M. Lavrijsen, Herman S. Overkleeft, Johannes M. F. G. Aerts, Joke A. Bouwstra*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Article number158673
Number of pages10
JournalBiochimica et Biophysica Acta-Molecular and Cell Biology of Lipids
Volume1865
Issue number6
DOIs
Publication statusPublished - Jun 2020

Keywords

  • Atopic dermatitis
  • Stratum corneum
  • Glucocerebrosidase
  • Acid sphingomyelinase
  • Mass spectrometry
  • Fluorescence microscopy
  • ACTIVATION-REGULATED CHEMOKINE
  • IN-SITU VISUALIZATION
  • BARRIER FUNCTION
  • SERUM THYMUS
  • FILAGGRIN
  • ORGANIZATION
  • MAINTENANCE
  • PRECURSORS
  • BIOMARKERS
  • CHILDREN

Cite this

Boer, D. E. C., van Smeden, J., Al-Khakany, H., Melnik, E., van Dijk, R., Absalah, S., Vreeken, R. J., Haenen, C. C. P., Lavrijsen, A. P. M., Overkleeft, H. S., Aerts, J. M. F. G., & Bouwstra, J. A. (2020). Skin of atopic dermatitis patients shows disturbed beta-glucocerebrosidase and acid sphingomyelinase activity that relates to changes in stratum corneum lipid composition. Biochimica et Biophysica Acta-Molecular and Cell Biology of Lipids, 1865(6), [158673]. https://doi.org/10.1016/j.bbalip.2020.158673