Skin of atopic dermatitis patients shows disturbed β-glucocerebrosidase and acid sphingomyelinase activity that relates to changes in stratum corneum lipid composition

Daphne E. C. Boer, Jeroen van Smeden, Hanin Al-Khakany, Elizaveta Melnik, Rianne van Dijk, Samira Absalah, Rob J. Vreeken, Caroline C. P. Haenen, Adriana P. M. Lavrijsen, Herman S. Overkleeft, Johannes M. F. G. Aerts, Joke A. Bouwstra*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Article number158673
Number of pages10
JournalBiochimica et Biophysica Acta-Molecular and Cell Biology of Lipids
Volume1865
Issue number6
DOIs
Publication statusPublished - Jun 2020

Keywords

  • Atopic dermatitis
  • Stratum corneum
  • Glucocerebrosidase
  • Acid sphingomyelinase
  • Mass spectrometry
  • Fluorescence microscopy
  • ACTIVATION-REGULATED CHEMOKINE
  • IN-SITU VISUALIZATION
  • BARRIER FUNCTION
  • SERUM THYMUS
  • FILAGGRIN
  • ORGANIZATION
  • MAINTENANCE
  • PRECURSORS
  • BIOMARKERS
  • CHILDREN

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