Skeletal health in adult patients with classic galactosemia

L. A. Batey, C. K. Welt, F. Rohr, A. Wessel, V. Anastasoaie, H. A. Feldman, C. -Y. Guo, E. Rubio-Gozalbo, G. Berry, C. M. Gordon*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


This study evaluated bone health in adults with galactosemia. Associations between bone mineral density (BMD) and nutritional and biochemical variables were explored. Calcium level predicted hip and spine BMD, and gonadotropin levels were inversely associated with spinal BMD in women. These results afford insights into management strategies for these patients. Bone loss is a complication of galactosemia. Dietary restriction, primary ovarian insufficiency in women, and disease-related alterations of bone metabolism may contribute. This study examined relationships between clinical factors and BMD in patients with galactosemia. This cross-sectional sample included 33 adults (16 women) with classic galactosemia, mean age 32.0 +/- 11.8 years. BMD was measured by dual-energy X-ray absorptiometry, and was correlated with age, height, weight, fractures, nutritional factors, hormonal status, and bone biomarkers. There was a significant difference in hip BMD between women and men (0.799 vs. 0.896 g/cm(2), p = 0.014). The percentage of subjects with BMD-Z
Original languageEnglish
Pages (from-to)501-509
JournalOsteoporosis International
Issue number2
Publication statusPublished - Feb 2013


  • Bone density
  • Calcium
  • Galactosemia
  • Premature ovarian insufficiency
  • Vitamin D


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