Simulation of mouse and rat spermatogenesis to inform genotoxicity testing using OECD test guideline 488

Francesco Marchetti*, Marilyn Aardema, Carol Beevers, Jan van Benthem, George R. Douglas, Roger Godschalk, Carole L. Yauk, Robert Young, Andrew Williams

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Pages (from-to)19-28
Number of pages10
JournalMutation Research-Genetic Toxicology and Environmental Mutagenesis
Volume832
DOIs
Publication statusPublished - Aug 2018

Keywords

  • Mutations
  • Germ cells
  • Transgene
  • Test guideline
  • Rodent
  • SPERMATOGONIAL STEM-CELLS
  • GERM-CELLS
  • LIFE-HISTORY
  • ADULT RATS
  • CYCLE
  • PROLIFERATION
  • APOPTOSIS
  • SPERMATOCYTES
  • MUTAGENICITY
  • POPULATION

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