Short-term western diet causes rapid and lasting alterations of bone marrow physiology

Mariaelvy Bianchini*, Zoe Moeller-Ramon, Christian Weber, Remco Megens, Johan Duchene*

*Corresponding author for this work

Research output: Contribution to journalComment/Letter to the editorAcademicpeer-review

Abstract

Dietary factors have a significant impact on overall health and western diet (WD) disrupts arterial homeostasis, thereby promoting atherosclerosis. In our study, we investigated the effects of short-term WD on bone marrow vasculature and hematopoiesis in hypercholesterolemic mice. We found that WD rapidly remodels bone marrow arterioles, and these alterations persist even after WD cessation. The proximity between hematopoietic stem cells (HSCs) and arterioles increased with short-term WD, which was associated with a reduced HSC counts as well as an increased number of progenitor cells and a higher production of myeloid cells. Additionally, the remaining HSCs showed increased proliferation, potentially raising susceptibility to clonal hematopoiesis. Collectively, our findings show that short-term WD dramatically alters the bone marrow physiology with lasting consequences.
Original languageEnglish
Pages (from-to)1100-1104
Number of pages5
JournalThrombosis and Haemostasis
Volume123
Issue number11
Early online date21 Sept 2023
DOIs
Publication statusPublished - Nov 2023

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