Short Duration Alagebrium Chloride Therapy Prediabetes Does Not Inhibit Progression to Autoimmune Diabetes in an Experimental Model

Danielle J. Borg, Pouya Faridi, Kai Lin Giam, Peta Reeves, Amelia K. Fotheringham, Domenica A. McCarthy, Sherman Leung, Micheal S. Ward, Brooke E. Harcourt, Rochelle Ayala, Jean L. Scheijen, David Briskey, Nadine L. Dudek, Casper G. Schalkwijk, Raymond Steptoe, Anthony W. Purcell, Josephine M. Forbes*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Article number426
Number of pages21
JournalMetabolites
Volume11
Issue number7
DOIs
Publication statusPublished - Jul 2021

Keywords

  • advanced glycation end products
  • alagebrium chloride
  • cross-link breaker
  • immunopeptidome
  • NOD mouse
  • autoimmune diabetes
  • type 1 diabetes
  • GLYCATION END-PRODUCTS
  • BETA-CELL DYSFUNCTION
  • T-CELLS
  • INSULIN-SECRETION
  • DENDRITIC CELLS
  • LYMPH-NODES
  • TYPE-1
  • RAGE
  • EXPRESSION
  • RECEPTOR

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