Shear stress activates ADAM10 sheddase to regulate Notch1 via the Piezo1 force sensor in endothelial cells

Vincenza Caolo, Marjolaine Debant, Naima Endesh, T Simon Futers, Laeticia Lichtenstein, Fiona Bartoli, Gregory Parsonage, Elizabeth Av Jones, David J Beech

Research output: Contribution to journalArticleAcademicpeer-review

9 Citations (Web of Science)
Original languageEnglish
Article number50684
Number of pages18
JournalElife
Volume9
DOIs
Publication statusPublished - 2 Jun 2020
Externally publishedYes

Keywords

  • ADAM10 Protein/metabolism
  • Amyloid Precursor Protein Secretases/metabolism
  • Animals
  • Cells, Cultured
  • Endothelial Cells/metabolism
  • Enzyme Activation
  • Gene Expression Regulation
  • Humans
  • Ion Channels/antagonists & inhibitors
  • Male
  • Membrane Proteins/metabolism
  • Mice
  • Mice, Inbred C57BL
  • Protein Domains
  • Receptor, Notch1/metabolism
  • Stress, Mechanical
  • Transcription Factor HES-1/genetics
  • HOMEOSTASIS
  • PRESSURE
  • DISINTEGRIN
  • ION-CHANNEL
  • INHIBITORS
  • HEALTH

Cite this