Seroma formation after mastectomy: A systematic review and network meta-analysis of different flap fixation techniques

Merel A. Spiekerman van Weezelenburg; Jean H. T. Daemen; Sander M. J. van Kuijk; Elisabeth R. M. van Haaren; Alfred Janssen; Yvonne L. J. Vissers; Geerard L. Beets; James van Bastelaar

doi:10.1002/jso.27589

Seroma formation after mastectomy: A systematic review and network meta-analysis of different flap fixation techniques

Merel A. Spiekerman van Weezelenburg^*, Jean H. T. Daemen, Sander M. J. van Kuijk, Elisabeth R. M. van Haaren, Alfred Janssen, Yvonne L. J. Vissers, Geerard L. Beets, James van Bastelaar

^*Corresponding author for this work

Research output: Contribution to journal › (Systematic) Review article › peer-review

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Abstract

Flap fixation is the most promising solution to prevent seroma formation after mastectomy. In this systematic review with network meta-analysis (NMA), three different techniques were compared. The NMA included 25 articles, comprising 3423 patients, and revealed that sutures are superior to tissue glue in preventing clinically significant seroma. In addition, running sutures seemed to be superior to interrupted sutures. An RCT comparing these suture techniques seems necessary, given the quality and nature of existing literature.

Original language	English
Number of pages	10
Journal	Journal of Surgical Oncology
Early online date	1 Jan 2024
DOIs	https://doi.org/10.1002/jso.27589
Publication status	Published - 1 Jan 2024

Keywords

flap fixation
interrupted sutures
mastectomy
running sutures
seroma
tissue glue
BREAST-CANCER SURGERY
DEAD SPACE
INTERVENTIONS
DISSECTION
RATES
RISK

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title = "Seroma formation after mastectomy: A systematic review and network meta-analysis of different flap fixation techniques",

abstract = "Flap fixation is the most promising solution to prevent seroma formation after mastectomy. In this systematic review with network meta-analysis (NMA), three different techniques were compared. The NMA included 25 articles, comprising 3423 patients, and revealed that sutures are superior to tissue glue in preventing clinically significant seroma. In addition, running sutures seemed to be superior to interrupted sutures. An RCT comparing these suture techniques seems necessary, given the quality and nature of existing literature.",

keywords = "flap fixation, interrupted sutures, mastectomy, running sutures, seroma, tissue glue, BREAST-CANCER SURGERY, DEAD SPACE, INTERVENTIONS, DISSECTION, RATES, RISK",

author = "{van Weezelenburg}, {Merel A. Spiekerman} and Daemen, {Jean H. T.} and {van Kuijk}, {Sander M. J.} and {van Haaren}, {Elisabeth R. M.} and Alfred Janssen and Vissers, {Yvonne L. J.} and Beets, {Geerard L.} and {van Bastelaar}, James",

year = "2024",

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doi = "10.1002/jso.27589",

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journal = "Journal of Surgical Oncology",

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publisher = "Wiley",

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TY - JOUR

T1 - Seroma formation after mastectomy

T2 - A systematic review and network meta-analysis of different flap fixation techniques

AU - van Weezelenburg, Merel A. Spiekerman

AU - Daemen, Jean H. T.

AU - van Kuijk, Sander M. J.

AU - van Haaren, Elisabeth R. M.

AU - Janssen, Alfred

AU - Vissers, Yvonne L. J.

AU - Beets, Geerard L.

AU - van Bastelaar, James

PY - 2024/1/1

Y1 - 2024/1/1

N2 - Flap fixation is the most promising solution to prevent seroma formation after mastectomy. In this systematic review with network meta-analysis (NMA), three different techniques were compared. The NMA included 25 articles, comprising 3423 patients, and revealed that sutures are superior to tissue glue in preventing clinically significant seroma. In addition, running sutures seemed to be superior to interrupted sutures. An RCT comparing these suture techniques seems necessary, given the quality and nature of existing literature.

AB - Flap fixation is the most promising solution to prevent seroma formation after mastectomy. In this systematic review with network meta-analysis (NMA), three different techniques were compared. The NMA included 25 articles, comprising 3423 patients, and revealed that sutures are superior to tissue glue in preventing clinically significant seroma. In addition, running sutures seemed to be superior to interrupted sutures. An RCT comparing these suture techniques seems necessary, given the quality and nature of existing literature.

KW - flap fixation

KW - interrupted sutures

KW - mastectomy

KW - running sutures

KW - seroma

KW - tissue glue

KW - BREAST-CANCER SURGERY

KW - DEAD SPACE

KW - INTERVENTIONS

KW - DISSECTION

KW - RATES

KW - RISK

U2 - 10.1002/jso.27589

DO - 10.1002/jso.27589

M3 - (Systematic) Review article

SN - 0022-4790

JO - Journal of Surgical Oncology

JF - Journal of Surgical Oncology

ER -